Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Nicolle H Rekers; Catharina M L Zegers; Wilfred Tv Germeraad; Ludwig Dubois; Philippe Lambin

doi:10.1080/2162402X.2015.1021541

Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2

Nicolle H Rekers^*, Catharina M L Zegers, Wilfred Tv Germeraad, Ludwig Dubois, Philippe Lambin

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

Original language	English
Article number	e1021541
Journal	OncoImmunology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2015.1021541
Publication status	Published - Aug 2015

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10.1080/2162402X.2015.1021541

Cite this

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title = "Long-lasting antitumor effects provided by radiotherapy combined with the immunocytokine L19-IL2",

abstract = "Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.",

author = "Rekers, {Nicolle H} and Zegers, {Catharina M L} and Germeraad, {Wilfred Tv} and Ludwig Dubois and Philippe Lambin",

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AU - Rekers, Nicolle H

AU - Zegers, Catharina M L

AU - Germeraad, Wilfred Tv

AU - Dubois, Ludwig

AU - Lambin, Philippe

PY - 2015/8

Y1 - 2015/8

N2 - Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

AB - Recently, we have shown that radiotherapy (RT) combined with L19-IL2 can induce a long-lasting antitumor effect, dependent on ED-B expression and infiltration of cytotoxic T cells. These findings will be translated to a Phase I clinical study (NCT02086721) in patients with oligometastatic solid tumors. See this link for the animation: http://youtu.be/xHbwQuCTkRc.

U2 - 10.1080/2162402X.2015.1021541

DO - 10.1080/2162402X.2015.1021541

M3 - Editorial

C2 - 26405576

SN - 2162-4011

VL - 4

JO - OncoImmunology

JF - OncoImmunology

IS - 8

M1 - e1021541

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