Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: towards a multi-biomarker approach.

M.B. Lobbes*, M.E. Kooi, E. Lutgens, V. Lima Passos, S.H.J.G. Braat, M.J.M. Rousch, H. ten Cate, J.M. van Engelshoven, M.J. Daemen, S. Heeneman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.
Original languageEnglish
Number of pages9
JournalInternational Journal of Vascular Medicine
Volume2010
Issue number726207
DOIs
Publication statusPublished - 1 Jan 2010

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