Research output

Lateral frontal pole and relational processing: activation patterns and connectivity profile

Research output: Contribution to journalArticleAcademicpeer-review

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Lateral frontal pole and relational processing : activation patterns and connectivity profile. / Hartogsveld, Bart; Bramson, Bob; Vijayakumar, Suhas; van Campen, A Dilene; Marques, José P; Roelofs, Karin; Toni, Ivan; Bekkering, Harold; Mars, Rogier B.

In: Behavioural Brain Research, Vol. 355, 14.12.2018, p. 2-11.

Research output: Contribution to journalArticleAcademicpeer-review

Harvard

Hartogsveld, B, Bramson, B, Vijayakumar, S, van Campen, AD, Marques, JP, Roelofs, K, Toni, I, Bekkering, H & Mars, RB 2018, 'Lateral frontal pole and relational processing: activation patterns and connectivity profile', Behavioural Brain Research, vol. 355, pp. 2-11. https://doi.org/10.1016/j.bbr.2017.08.003

APA

Hartogsveld, B., Bramson, B., Vijayakumar, S., van Campen, A. D., Marques, J. P., Roelofs, K., ... Mars, R. B. (2018). Lateral frontal pole and relational processing: activation patterns and connectivity profile. Behavioural Brain Research, 355, 2-11. https://doi.org/10.1016/j.bbr.2017.08.003

Vancouver

Author

Hartogsveld, Bart ; Bramson, Bob ; Vijayakumar, Suhas ; van Campen, A Dilene ; Marques, José P ; Roelofs, Karin ; Toni, Ivan ; Bekkering, Harold ; Mars, Rogier B. / Lateral frontal pole and relational processing : activation patterns and connectivity profile. In: Behavioural Brain Research. 2018 ; Vol. 355. pp. 2-11.

Bibtex

@article{14513c3ee38d4516a152e0a9ac151771,
title = "Lateral frontal pole and relational processing: activation patterns and connectivity profile",
abstract = "The functional contribution of the lateral frontal cortex to behavior has been discussed with reference to several higher-order cognitive domains. In a separate line of research, recent studies have focused on the anatomical organization of this part of the brain. These different approaches are rarely combined. Here, we combine previous work using anatomical connectivity that identified a lateral subdivision of the human frontal pole and work that suggested a general role for rostrolateral prefrontal cortex in processing higher-order relations, irrespective of the type of information. We asked healthy human volunteers to judge the relationship between pairs of stimuli, a task previously suggested to engage the lateral frontal pole. Presenting both shape and face stimuli, we indeed observed overlapping activation of the lateral prefrontal cortex when subjects judged relations between pairs. Using resting state functional MRI, we confirmed that the activated region's whole-brain connectivity most strongly resembles that of the lateral frontal pole. Using diffusion MRI, we showed that the pattern of connections of this region with the main association fibers again is most similar to that of the lateral frontal pole, consistent with the observation that it is this anatomical region that is involved in relational processing.",
keywords = "Relational processing, fMRI, Frontal pole, Connectivity, Prefrontal cortex, ROSTROLATERAL PREFRONTAL CORTEX, STATE FUNCTIONAL CONNECTIVITY, FACE-RECOGNITION ALGORITHMS, COGNITIVE CONTROL, LOCAL MORPHOLOGY, DECISION-MAKING, PARIETAL CORTEX, AREAS, TRACTOGRAPHY, INFERENCE, Visual Perception/physiology, Humans, Neural Pathways/anatomy & histology, Male, Young Adult, Association, Adult, Judgment/physiology, Frontal Lobe/anatomy & histology, Magnetic Resonance Imaging, Adolescent, Models, Neurological",
author = "Bart Hartogsveld and Bob Bramson and Suhas Vijayakumar and {van Campen}, {A Dilene} and Marques, {Jos{\'e} P} and Karin Roelofs and Ivan Toni and Harold Bekkering and Mars, {Rogier B}",
note = "Copyright {\circledC} 2018 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2018",
month = "12",
day = "14",
doi = "10.1016/j.bbr.2017.08.003",
language = "English",
volume = "355",
pages = "2--11",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier Science",

}

RIS

TY - JOUR

T1 - Lateral frontal pole and relational processing

T2 - Behavioural Brain Research

AU - Hartogsveld, Bart

AU - Bramson, Bob

AU - Vijayakumar, Suhas

AU - van Campen, A Dilene

AU - Marques, José P

AU - Roelofs, Karin

AU - Toni, Ivan

AU - Bekkering, Harold

AU - Mars, Rogier B

N1 - Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2018/12/14

Y1 - 2018/12/14

N2 - The functional contribution of the lateral frontal cortex to behavior has been discussed with reference to several higher-order cognitive domains. In a separate line of research, recent studies have focused on the anatomical organization of this part of the brain. These different approaches are rarely combined. Here, we combine previous work using anatomical connectivity that identified a lateral subdivision of the human frontal pole and work that suggested a general role for rostrolateral prefrontal cortex in processing higher-order relations, irrespective of the type of information. We asked healthy human volunteers to judge the relationship between pairs of stimuli, a task previously suggested to engage the lateral frontal pole. Presenting both shape and face stimuli, we indeed observed overlapping activation of the lateral prefrontal cortex when subjects judged relations between pairs. Using resting state functional MRI, we confirmed that the activated region's whole-brain connectivity most strongly resembles that of the lateral frontal pole. Using diffusion MRI, we showed that the pattern of connections of this region with the main association fibers again is most similar to that of the lateral frontal pole, consistent with the observation that it is this anatomical region that is involved in relational processing.

AB - The functional contribution of the lateral frontal cortex to behavior has been discussed with reference to several higher-order cognitive domains. In a separate line of research, recent studies have focused on the anatomical organization of this part of the brain. These different approaches are rarely combined. Here, we combine previous work using anatomical connectivity that identified a lateral subdivision of the human frontal pole and work that suggested a general role for rostrolateral prefrontal cortex in processing higher-order relations, irrespective of the type of information. We asked healthy human volunteers to judge the relationship between pairs of stimuli, a task previously suggested to engage the lateral frontal pole. Presenting both shape and face stimuli, we indeed observed overlapping activation of the lateral prefrontal cortex when subjects judged relations between pairs. Using resting state functional MRI, we confirmed that the activated region's whole-brain connectivity most strongly resembles that of the lateral frontal pole. Using diffusion MRI, we showed that the pattern of connections of this region with the main association fibers again is most similar to that of the lateral frontal pole, consistent with the observation that it is this anatomical region that is involved in relational processing.

KW - Relational processing

KW - fMRI

KW - Frontal pole

KW - Connectivity

KW - Prefrontal cortex

KW - ROSTROLATERAL PREFRONTAL CORTEX

KW - STATE FUNCTIONAL CONNECTIVITY

KW - FACE-RECOGNITION ALGORITHMS

KW - COGNITIVE CONTROL

KW - LOCAL MORPHOLOGY

KW - DECISION-MAKING

KW - PARIETAL CORTEX

KW - AREAS

KW - TRACTOGRAPHY

KW - INFERENCE

KW - Visual Perception/physiology

KW - Humans

KW - Neural Pathways/anatomy & histology

KW - Male

KW - Young Adult

KW - Association

KW - Adult

KW - Judgment/physiology

KW - Frontal Lobe/anatomy & histology

KW - Magnetic Resonance Imaging

KW - Adolescent

KW - Models, Neurological

U2 - 10.1016/j.bbr.2017.08.003

DO - 10.1016/j.bbr.2017.08.003

M3 - Article

VL - 355

SP - 2

EP - 11

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -