Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

S. R. Ellis; J. Soltwisch; M. R. L. Paine; K. Dreisewerd; R. M. A. Heeren

doi:10.1039/c7cc02325a

Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

S. R. Ellis^*, J. Soltwisch, M. R. L. Paine, K. Dreisewerd, R. M. A. Heeren

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to B100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

Original language	English
Pages (from-to)	7246-7249
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	53
DOIs	https://doi.org/10.1039/c7cc02325a
Publication status	Published - 7 Jul 2017

Keywords

PROTEINS

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10.1039/c7cc02325a

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Cite this

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abstract = "Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to B100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.",

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AU - Heeren, R. M. A.

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AB - Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to B100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

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