Abstract
Background: Obesity was often associated with low high-density lipoprotein (HDL) cholesterol concentration, which is an established cardiovascular risk factor. Objectives: To evaluate the association of HDL-cholesterol concentration with fat and muscle mass in children and adolescents. Methods: Data of the National Health and Nutrition Examination Survey (1999-2004) were used to estimate fat and muscle mass by dual-energy X-ray absorptiometry (DXA) of the participants who had also an examination of their lipid profiles. Fat mass was assessed by DXA-determined fat mass index (FMI). Muscle mass was operationalized by appendicular lean mass index (LMI). Low HDL-cholesterol concentration was defined as Results: For the evaluation of the association of HDL-cholesterol concentration with FMI and LMI Z-scores, the data of 6288 children and adolescents (age 8-19 years) (2535 females) were eligible. In the study population, the prevalence of low HDL-cholesterol concentration increased with rising FMI and appendicular LMI Z-scores. Conclusions: The study results suggested that there is a counterintuitive, inverse association of muscle mass and HDL-cholesterol concentration.
Original language | English |
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Pages (from-to) | 476-484 |
Number of pages | 9 |
Journal | Childhood obesity |
Volume | 15 |
Issue number | 7 |
Early online date | 8 Jul 2019 |
DOIs | |
Publication status | Published - 1 Oct 2019 |
Keywords
- children
- fat mass
- HDL cholesterol
- muscle mass
- reference centiles
- CARDIOVASCULAR RISK-FACTORS
- X-RAY ABSORPTIOMETRY
- FAT-FREE MASS
- BODY-COMPOSITION
- CENTILE CURVES
- SERUM-LIPIDS
- ADIPOSITY
- POPULATION
- OBESITY
- AGE