Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with inoperable meningioma

Frederik A. Verburg; Martin Wiesmann; Georg Neuloh; Felix M. Mottaghy; Marc-Alexander Brockmann

doi:10.1055/a-0802-5039

Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with inoperable meningioma

Frederik A. Verburg^*, Martin Wiesmann, Georg Neuloh, Felix M. Mottaghy, Marc-Alexander Brockmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0, Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy.

Methods Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed.

Results Selective arterial infusion of Ga-68-DOTATATE increased the median value for the maximum standardized uptake value (SUV) by 2.6-fold (median venous: 7.1, median arterial: 21.6; range 2.0-5.0) and the median value for mean SUV by 2.7-fold (median venous: 4.3, median arterial: 11.2; range 1.6-5.6) compared to systemic intravenous infusion. Arterial application was well tolerated by all patients without complications. When compared to liver uptake, intravenous tracer uptake was insufficient for PRRT, whereas tracer uptake after superselective intraarterial tracer injection was sufficient to allow for peptide receptor radionuclide therapy (PRRT) in all patients.

Conclusion Insufficient tracer uptake in meningiomas after intravenous application of Ga-68-DOTATATE may be safely increased by a factor of 2-5 using transfemoral selective intraarterial tracer application.

Original language	English
Pages (from-to)	23-27
Number of pages	5
Journal	Nuklearmedizin
Volume	58
Issue number	1
DOIs	https://doi.org/10.1055/a-0802-5039
Publication status	Published - Feb 2019

Keywords

Meningioma
somatostatin receptor
radionuclide therapy
arterial application
THERAPY
ARTERIAL

Access to Document

10.1055/a-0802-5039

Cite this

@article{3fc79dec36834bc0868ecb0887a644a7,

title = "Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with inoperable meningioma",

abstract = "Aim Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0, Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy.Methods Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed.Results Selective arterial infusion of Ga-68-DOTATATE increased the median value for the maximum standardized uptake value (SUV) by 2.6-fold (median venous: 7.1, median arterial: 21.6; range 2.0-5.0) and the median value for mean SUV by 2.7-fold (median venous: 4.3, median arterial: 11.2; range 1.6-5.6) compared to systemic intravenous infusion. Arterial application was well tolerated by all patients without complications. When compared to liver uptake, intravenous tracer uptake was insufficient for PRRT, whereas tracer uptake after superselective intraarterial tracer injection was sufficient to allow for peptide receptor radionuclide therapy (PRRT) in all patients.Conclusion Insufficient tracer uptake in meningiomas after intravenous application of Ga-68-DOTATATE may be safely increased by a factor of 2-5 using transfemoral selective intraarterial tracer application.",

keywords = "Meningioma, somatostatin receptor, radionuclide therapy, arterial application, THERAPY, ARTERIAL",

author = "Verburg, {Frederik A.} and Martin Wiesmann and Georg Neuloh and Mottaghy, {Felix M.} and Marc-Alexander Brockmann",

note = "Publisher Copyright: {\textcopyright} 2019 Georg Thieme Verlag KG Stuttgart · New York.",

year = "2019",

month = feb,

doi = "10.1055/a-0802-5039",

language = "English",

volume = "58",

pages = "23--27",

journal = "Nuklearmedizin",

issn = "0029-5566",

publisher = "Georg Thieme Verlag",

number = "1",

}

TY - JOUR

T1 - Intraindividual comparison of selective intraarterial versus systemic intravenous 68Ga-DOTATATE PET/CT in patients with inoperable meningioma

AU - Verburg, Frederik A.

AU - Wiesmann, Martin

AU - Neuloh, Georg

AU - Mottaghy, Felix M.

AU - Brockmann, Marc-Alexander

PY - 2019/2

Y1 - 2019/2

N2 - Aim Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0, Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy.Methods Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed.Results Selective arterial infusion of Ga-68-DOTATATE increased the median value for the maximum standardized uptake value (SUV) by 2.6-fold (median venous: 7.1, median arterial: 21.6; range 2.0-5.0) and the median value for mean SUV by 2.7-fold (median venous: 4.3, median arterial: 11.2; range 1.6-5.6) compared to systemic intravenous infusion. Arterial application was well tolerated by all patients without complications. When compared to liver uptake, intravenous tracer uptake was insufficient for PRRT, whereas tracer uptake after superselective intraarterial tracer injection was sufficient to allow for peptide receptor radionuclide therapy (PRRT) in all patients.Conclusion Insufficient tracer uptake in meningiomas after intravenous application of Ga-68-DOTATATE may be safely increased by a factor of 2-5 using transfemoral selective intraarterial tracer application.

AB - Aim Here we describe the results of superselective intraarterial application of diagnostic Ga-68-DOTA0, Tyr3-octreotate (Ga-68-DOTATATE) in a series of patients with inoperable WHO grade II meningiomas which were no longer amenable to radiotherapy.Methods Four patients with inoperable WHO grade II meningioma underwent systemic venous infusion of Ga-68-DOTATATE followed by PET/CT. Ga-68-DOTATATE application was repeated intraarterially via transfemoral catheterization of vessels supplying the meningioma and another PET/CT was performed.Results Selective arterial infusion of Ga-68-DOTATATE increased the median value for the maximum standardized uptake value (SUV) by 2.6-fold (median venous: 7.1, median arterial: 21.6; range 2.0-5.0) and the median value for mean SUV by 2.7-fold (median venous: 4.3, median arterial: 11.2; range 1.6-5.6) compared to systemic intravenous infusion. Arterial application was well tolerated by all patients without complications. When compared to liver uptake, intravenous tracer uptake was insufficient for PRRT, whereas tracer uptake after superselective intraarterial tracer injection was sufficient to allow for peptide receptor radionuclide therapy (PRRT) in all patients.Conclusion Insufficient tracer uptake in meningiomas after intravenous application of Ga-68-DOTATATE may be safely increased by a factor of 2-5 using transfemoral selective intraarterial tracer application.

KW - Meningioma

KW - somatostatin receptor

KW - radionuclide therapy

KW - arterial application

KW - THERAPY

KW - ARTERIAL

U2 - 10.1055/a-0802-5039

DO - 10.1055/a-0802-5039

M3 - Article

C2 - 30769370

SN - 0029-5566

VL - 58

SP - 23

EP - 27

JO - Nuklearmedizin

JF - Nuklearmedizin

IS - 1

ER -