Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

Ann Hoeben; Linda van de Winkel; Frank Hoebers; Kenneth Kross; Chantal Driessen; Pieter Slootweg; Vivianne C. G. Tjan-Heijnen; Carla van Herpen

doi:10.1002/hed.24416

Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment

Ann Hoeben^*, Linda van de Winkel, Frank Hoebers, Kenneth Kross, Chantal Driessen, Pieter Slootweg, Vivianne C. G. Tjan-Heijnen, Carla van Herpen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background. Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.
Methods. Articles on ITAC histopathology, molecular profile, and current
treatment options of this specific tumor were identified and reviewed,
using the electronic databases Pubmed, Medline, Cochrane, and Web of Science.
Results. This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.Conclusion. More translational research is needed to identify druggabletargets that may lead to a personalized treatment plan in order toimprove long-term outcome in patients with locally advanced and/or metastasized ITAC

Original language	English
Pages (from-to)	1564-1570
Number of pages	7
Journal	Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
Volume	38
DOIs	https://doi.org/10.1002/hed.24416
Publication status	Published - Oct 2016

Keywords

intestinal-type adenocarcinoma
sinonasal adenocarcinoma
treatment
gene expression
pathology

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10.1002/hed.24416

Cite this

@article{067af3967f444db180655c222161b42c,

title = "Intestinal-type sinonasal adenocarcinomas: The road to molecular diagnosis and personalized treatment",

abstract = "Background. Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.Methods. Articles on ITAC histopathology, molecular profile, and currenttreatment options of this specific tumor were identified and reviewed,using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. Results. This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.Conclusion. More translational research is needed to identify druggabletargets that may lead to a personalized treatment plan in order toimprove long-term outcome in patients with locally advanced and/or metastasized ITAC",

keywords = "intestinal-type adenocarcinoma, sinonasal adenocarcinoma, treatment, gene expression, pathology",

author = "Ann Hoeben and {van de Winkel}, Linda and Frank Hoebers and Kenneth Kross and Chantal Driessen and Pieter Slootweg and Tjan-Heijnen, {Vivianne C. G.} and {van Herpen}, Carla",

year = "2016",

month = oct,

doi = "10.1002/hed.24416",

language = "English",

volume = "38",

pages = "1564--1570",

journal = "Head and Neck-Journal for the Sciences and Specialties of the Head and Neck",

issn = "1043-3074",

publisher = "Wiley",

}

TY - JOUR

T1 - Intestinal-type sinonasal adenocarcinomas

T2 - The road to molecular diagnosis and personalized treatment

AU - Hoeben, Ann

AU - van de Winkel, Linda

AU - Hoebers, Frank

AU - Kross, Kenneth

AU - Driessen, Chantal

AU - Slootweg, Pieter

AU - Tjan-Heijnen, Vivianne C. G.

AU - van Herpen, Carla

PY - 2016/10

Y1 - 2016/10

N2 - Background. Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.Methods. Articles on ITAC histopathology, molecular profile, and currenttreatment options of this specific tumor were identified and reviewed,using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. Results. This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.Conclusion. More translational research is needed to identify druggabletargets that may lead to a personalized treatment plan in order toimprove long-term outcome in patients with locally advanced and/or metastasized ITAC

AB - Background. Sinonasal intestinal-type adenocarcinomas (ITACs) are epithelial tumors of the nasal cavity and the paranasal sinuses, often related to professional exposure to organic dust, mainly wood or leather. It is a rare cancer. If resectable, surgery is the treatment of choice. Postoperative radiotherapy is often indicated to increase local control. Systemic treatment (chemotherapy, targeted agents, or immunotherapy) of irresectable ITACs and/or metastasized disease is less standardized.Methods. Articles on ITAC histopathology, molecular profile, and currenttreatment options of this specific tumor were identified and reviewed,using the electronic databases Pubmed, Medline, Cochrane, and Web of Science. Results. This article reviews what is currently known on the histopathology, tumorigenesis, molecular characteristics, and standardized treatment options of ITAC.Conclusion. More translational research is needed to identify druggabletargets that may lead to a personalized treatment plan in order toimprove long-term outcome in patients with locally advanced and/or metastasized ITAC

KW - intestinal-type adenocarcinoma

KW - sinonasal adenocarcinoma

KW - treatment

KW - gene expression

KW - pathology

U2 - 10.1002/hed.24416

DO - 10.1002/hed.24416

M3 - Article

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SN - 1043-3074

VL - 38

SP - 1564

EP - 1570

JO - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

JF - Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

ER -