Abstract
Medicinal agents, beside occupational and environmental agents, remain one of the most common causes for interstitial lung diseases (ILD). A major problem with ILD is the recognition of the causative agent. In some cases more or less characteristic features of presentation are described. Often, the connection between drug-use and the development of related inflammatory damage or idiosyncratic toxicities is hard to recognize and objectify. Cocaine, a xenobiotic and the most commonly used illicit drug, causes serious medical and social problems. An increasing incidence of lung toxicity related to cocaine or crack-use is being reported worldwide. However, the mechanism of the resulting lung injury is not fully understood. This review summarizes possible molecular mechanisms explaining intra-individual variability in cocaine response and lung toxicity. The importance of including pharmacogenomics in the work-up of patients with suspected drug-induced lung toxicity is highlighted.
Original language | English |
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Pages (from-to) | 5607-5611 |
Number of pages | 5 |
Journal | Current Medicinal Chemistry |
Volume | 19 |
Issue number | 33 |
DOIs | |
Publication status | Published - Nov 2012 |
Keywords
- Cocaine
- crack
- CYP450
- drug-induced toxicity
- interstitial lung diseases
- polymorphisms
- oxidative stress
- redox cycling
- nitroxide radicals
- cocaine metabolites
- biotransformation
- OBSTRUCTIVE PULMONARY-DISEASE
- OXIDATIVE STRESS
- BRONCHOALVEOLAR LAVAGE
- CHEMICAL TOXICITY
- CYTOCHROMES P450
- METABOLISM
- DRUGS
- CRACK
- VKORC1
- ANTICOAGULATION