International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)

Joachim Weis; Krzysztof A. Tomaszewski; Eva Hammerlid; Juan Ignacio Arraras; Thierry Conroy; Anne Lanceley; Heike Schmidt; Markus Wirtz; Susanne Singer; Monica Pinto; Mohamed Alm El-Din; Inge Compter; Bernhard Holzner; Dirk Hofmeister; Wei-Chu Chie; Marek Czeladzki; Amelie Harle; Louise Jones; Sabrina Ritter; Hans-Henning Flechtner; Andrew Bottomley; EORTC Quality of Life Group

doi:10.1093/jnci/djw273

International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)

Joachim Weis^*, Krzysztof A. Tomaszewski, Eva Hammerlid, Juan Ignacio Arraras, Thierry Conroy, Anne Lanceley, Heike Schmidt, Markus Wirtz, Susanne Singer, Monica Pinto, Mohamed Alm El-Din, Inge Compter, Bernhard Holzner, Dirk Hofmeister, Wei-Chu Chie, Marek Czeladzki, Amelie Harle, Louise Jones, Sabrina Ritter, Hans-Henning FlechtnerAndrew Bottomley, EORTC Quality of Life Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue.

Methods: The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries.

Results: A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability >= 0.60, factor reliability >= 0.82) and global model fit (GFI(t1 vertical bar t2) = 0.965/0.957, CFIt1 vertical bar t2 = 0.976/0.972, RMSEA(t1 vertical bar t2) = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: Rt1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90).

Conclusion: Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined.

Original language	English
Article number	273
Number of pages	8
Journal	Journal of the National Cancer Institute
Volume	109
Issue number	5
DOIs	https://doi.org/10.1093/jnci/djw273
Publication status	Published - May 2017

Keywords

MANAGEMENT
SYMPTOMS

Access to Document

10.1093/jnci/djw273

Cite this

Weis, J., Tomaszewski, K. A., Hammerlid, E., Ignacio Arraras, J., Conroy, T., Lanceley, A., Schmidt, H., Wirtz, M., Singer, S., Pinto, M., El-Din, M. A., Compter, I., Holzner, B., Hofmeister, D., Chie, W.-C., Czeladzki, M., Harle, A., Jones, L., Ritter, S., ... EORTC Quality of Life Group (2017). International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12). Journal of the National Cancer Institute, 109(5), Article 273. https://doi.org/10.1093/jnci/djw273

@article{ade58830360b4d20b3cb74ca47ea2ad3,

title = "International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)",

abstract = "Background: The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue.Methods: The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries.Results: A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability >= 0.60, factor reliability >= 0.82) and global model fit (GFI(t1 vertical bar t2) = 0.965/0.957, CFIt1 vertical bar t2 = 0.976/0.972, RMSEA(t1 vertical bar t2) = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: Rt1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90).Conclusion: Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined.",

keywords = "MANAGEMENT, SYMPTOMS",

author = "Joachim Weis and Tomaszewski, {Krzysztof A.} and Eva Hammerlid and {Ignacio Arraras}, Juan and Thierry Conroy and Anne Lanceley and Heike Schmidt and Markus Wirtz and Susanne Singer and Monica Pinto and El-Din, {Mohamed Alm} and Inge Compter and Bernhard Holzner and Dirk Hofmeister and Wei-Chu Chie and Marek Czeladzki and Amelie Harle and Louise Jones and Sabrina Ritter and Hans-Henning Flechtner and Andrew Bottomley and {EORTC Quality of Life Group}",

year = "2017",

month = may,

doi = "10.1093/jnci/djw273",

language = "English",

volume = "109",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "5",

}

Weis, J, Tomaszewski, KA, Hammerlid, E, Ignacio Arraras, J, Conroy, T, Lanceley, A, Schmidt, H, Wirtz, M, Singer, S, Pinto, M, El-Din, MA, Compter, I, Holzner, B, Hofmeister, D, Chie, W-C, Czeladzki, M, Harle, A, Jones, L, Ritter, S, Flechtner, H-H, Bottomley, A & EORTC Quality of Life Group 2017, 'International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)', Journal of the National Cancer Institute, vol. 109, no. 5, 273. https://doi.org/10.1093/jnci/djw273

TY - JOUR

T1 - International Psychometric Validation of an EORTC Quality of Life Module Measuring Cancer Related Fatigue (EORTC QLQ-FA12)

AU - Weis, Joachim

AU - Tomaszewski, Krzysztof A.

AU - Hammerlid, Eva

AU - Ignacio Arraras, Juan

AU - Conroy, Thierry

AU - Lanceley, Anne

AU - Schmidt, Heike

AU - Wirtz, Markus

AU - Singer, Susanne

AU - Pinto, Monica

AU - El-Din, Mohamed Alm

AU - Compter, Inge

AU - Holzner, Bernhard

AU - Hofmeister, Dirk

AU - Chie, Wei-Chu

AU - Czeladzki, Marek

AU - Harle, Amelie

AU - Jones, Louise

AU - Ritter, Sabrina

AU - Flechtner, Hans-Henning

AU - Bottomley, Andrew

AU - EORTC Quality of Life Group

PY - 2017/5

Y1 - 2017/5

N2 - Background: The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue.Methods: The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries.Results: A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability >= 0.60, factor reliability >= 0.82) and global model fit (GFI(t1 vertical bar t2) = 0.965/0.957, CFIt1 vertical bar t2 = 0.976/0.972, RMSEA(t1 vertical bar t2) = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: Rt1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90).Conclusion: Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined.

AB - Background: The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality of life core questionnaire (EORTC QLQ-C30). The module EORTC QLQ-FA13 assesses physical, cognitive, and emotional aspects of cancer-related fatigue.Methods: The methodology follows the EORTC guidelines for phase IV validation of modules. This paper focuses on the results of the psychometric validation of the factorial structure of the module. For validation and cross-validation confirmatory factor analysis (maximum likelihood estimation), intraclass correlation and Cronbach alpha for internal consistency were employed. The study involved an international multicenter collaboration of 11 European and non-European countries.Results: A total of 946 patients with various tumor diagnoses were enrolled. Based on the confirmatory factor analysis, we could approve the three-dimensional structure of the module. Removing one item and reassigning the factorial mapping of another item resulted in the EORTC QLQ-FA12. For the revised scale, we found evidence supporting good local (indicator reliability >= 0.60, factor reliability >= 0.82) and global model fit (GFI(t1 vertical bar t2) = 0.965/0.957, CFIt1 vertical bar t2 = 0.976/0.972, RMSEA(t1 vertical bar t2) = 0.060/0.069) for both measurement points. For each scale, test-retest reliability proved to be very good (intraclass correlation: Rt1-t2 = 0.905-0.921) and internal consistency proved to be good to high (Cronbach alpha = .79-.90).Conclusion: Based on the former phase III module, the multidimensional structure was revised as a phase IV module (EORTC FA12) with an improved scale structure. For a comprehensive validation of the EORTC FA12, further aspects of convergent and divergent validity as well as sensitivity to change should be determined.

KW - MANAGEMENT

KW - SYMPTOMS

U2 - 10.1093/jnci/djw273

DO - 10.1093/jnci/djw273

M3 - Article

C2 - 28376231

SN - 0027-8874

VL - 109

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 5

M1 - 273

ER -