Intermittent pacing therapy favorably modulates infarct remodeling

Andre Uitterdijk; Tirza Springeling; Kevin C. M. Hermans; Daphne Merkus; Vincent J. de Beer; Charlotte Gorsse-Bakker; Eric Mokelke; Evangelos P. Daskalopoulos; Piotr A. Wielopolski; Jack P. M. Cleutjens; W. Matthijs Blankesteijn; Frits W. Prinzen; Willem J. van der Giessen; Robert-Jan M. van Geuns; Dirk J. Duncker

doi:10.1007/s00395-017-0616-3

Intermittent pacing therapy favorably modulates infarct remodeling

Andre Uitterdijk, Tirza Springeling, Kevin C. M. Hermans, Daphne Merkus, Vincent J. de Beer, Charlotte Gorsse-Bakker, Eric Mokelke, Evangelos P. Daskalopoulos, Piotr A. Wielopolski, Jack P. M. Cleutjens, W. Matthijs Blankesteijn, Frits W. Prinzen, Willem J. van der Giessen, Robert-Jan M. van Geuns, Dirk J. Duncker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P

Original language	English
Article number	28
Number of pages	10
Journal	Basic Research in Cardiology
Volume	112
Issue number	3
DOIs	https://doi.org/10.1007/s00395-017-0616-3
Publication status	Published - May 2017

Keywords

Myocardial infarction
Myofibroblasts
Infarct geometry
Infarct expansion
Infarct healing
Swine
PRECONDITIONS RABBIT MYOCARDIUM
CORONARY-ARTERY-DISEASE
HEART-FAILURE
CARDIAC FIBROBLASTS
REPERFUSION INJURY
EXPANSION
SIZE
TARGET
TISSUE
SWINE

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Cite this

Uitterdijk, A., Springeling, T., Hermans, K. C. M., Merkus, D., de Beer, V. J., Gorsse-Bakker, C., Mokelke, E., Daskalopoulos, E. P., Wielopolski, P. A., Cleutjens, J. P. M., Blankesteijn, W. M., Prinzen, F. W., van der Giessen, W. J., van Geuns, R.-J. M., & Duncker, D. J. (2017). Intermittent pacing therapy favorably modulates infarct remodeling. Basic Research in Cardiology, 112(3), Article 28. https://doi.org/10.1007/s00395-017-0616-3

@article{5e63b52e3cc4444fa69fcc75ba1e5c3e,

title = "Intermittent pacing therapy favorably modulates infarct remodeling",

abstract = "Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P",

keywords = "Myocardial infarction, Myofibroblasts, Infarct geometry, Infarct expansion, Infarct healing, Swine, PRECONDITIONS RABBIT MYOCARDIUM, CORONARY-ARTERY-DISEASE, HEART-FAILURE, CARDIAC FIBROBLASTS, REPERFUSION INJURY, EXPANSION, SIZE, TARGET, TISSUE, SWINE",

author = "Andre Uitterdijk and Tirza Springeling and Hermans, {Kevin C. M.} and Daphne Merkus and {de Beer}, {Vincent J.} and Charlotte Gorsse-Bakker and Eric Mokelke and Daskalopoulos, {Evangelos P.} and Wielopolski, {Piotr A.} and Cleutjens, {Jack P. M.} and Blankesteijn, {W. Matthijs} and Prinzen, {Frits W.} and {van der Giessen}, {Willem J.} and {van Geuns}, {Robert-Jan M.} and Duncker, {Dirk J.}",

year = "2017",

month = may,

doi = "10.1007/s00395-017-0616-3",

language = "English",

volume = "112",

journal = "Basic Research in Cardiology",

issn = "0300-8428",

publisher = "Springer",

number = "3",

}

Uitterdijk, A, Springeling, T, Hermans, KCM, Merkus, D, de Beer, VJ, Gorsse-Bakker, C, Mokelke, E, Daskalopoulos, EP, Wielopolski, PA, Cleutjens, JPM , Blankesteijn, WM , Prinzen, FW, van der Giessen, WJ, van Geuns, R-JM & Duncker, DJ 2017, 'Intermittent pacing therapy favorably modulates infarct remodeling', Basic Research in Cardiology, vol. 112, no. 3, 28. https://doi.org/10.1007/s00395-017-0616-3

TY - JOUR

T1 - Intermittent pacing therapy favorably modulates infarct remodeling

AU - Uitterdijk, Andre

AU - Springeling, Tirza

AU - Hermans, Kevin C. M.

AU - Merkus, Daphne

AU - de Beer, Vincent J.

AU - Gorsse-Bakker, Charlotte

AU - Mokelke, Eric

AU - Daskalopoulos, Evangelos P.

AU - Wielopolski, Piotr A.

AU - Cleutjens, Jack P. M.

AU - Blankesteijn, W. Matthijs

AU - Prinzen, Frits W.

AU - van der Giessen, Willem J.

AU - van Geuns, Robert-Jan M.

AU - Duncker, Dirk J.

PY - 2017/5

Y1 - 2017/5

N2 - Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P

AB - Despite early revascularization, remodeling and dysfunction of the left ventricle (LV) after acute myocardial infarction (AMI) remain important therapeutic targets. Intermittent pacing therapy (IPT) of the LV can limit infarct size, when applied during early reperfusion. However, the effects of IPT on post-AMI LV remodeling and infarct healing are unknown. We therefore investigated the effects of IPT on global LV remodeling and infarct geometry in swine with a 3-day old AMI. For this purpose, fifteen pigs underwent 2 h ligation of the left circumflex coronary artery followed by reperfusion. An epicardial pacing lead was implanted in the peri-infarct zone. After three days, global LV remodeling and infarct geometry were assessed using magnetic resonance imaging (MRI). Animals were stratified into MI control and IPT groups. Thirty-five days post-AMI, follow-up MRI was obtained and myofibroblast content, markers of extracellular matrix (ECM) turnover and Wnt/frizzled signaling in infarct and non-infarct control tissue were studied. Results showed that IPT had no significant effect on global LV remodeling, function or infarct mass, but modulated infarct healing. In MI control pigs, infarct mass reduction was principally due to a 26.2 +/- 4.4% reduction in infarct thickness (P

KW - Myocardial infarction

KW - Myofibroblasts

KW - Infarct geometry

KW - Infarct expansion

KW - Infarct healing

KW - Swine

KW - PRECONDITIONS RABBIT MYOCARDIUM

KW - CORONARY-ARTERY-DISEASE

KW - HEART-FAILURE

KW - CARDIAC FIBROBLASTS

KW - REPERFUSION INJURY

KW - EXPANSION

KW - SIZE

KW - TARGET

KW - TISSUE

KW - SWINE

U2 - 10.1007/s00395-017-0616-3

DO - 10.1007/s00395-017-0616-3

M3 - Article

C2 - 28386775

SN - 0300-8428

VL - 112

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

IS - 3

M1 - 28

ER -