Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial

Danielle B. P. Eekers; Erik Roelofs; Macarena Cubillos-Mesias; Charles Niel; Robert Jan Smeenk; Ann Hoeben; Andre W. H. Minken; Marlies Granzier; Geert O. Janssens; Johannes H. A. M. Kaanders; Philippe Lambin; Esther G. C. Troost

doi:10.1080/0284186X.2018.1529424

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial

Danielle B. P. Eekers^*, Erik Roelofs, Macarena Cubillos-Mesias, Charles Niel, Robert Jan Smeenk, Ann Hoeben, Andre W. H. Minken, Marlies Granzier, Geert O. Janssens, Johannes H. A. M. Kaanders, Philippe Lambin, Esther G. C. Troost

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and purpose: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). The aim of this comparative in silico study was to determine these dosimetric differences in delivered doses.Material and methods: Imaging datasets of 25 LGG patients having undergone postoperative radiotherapy were included. For each of these patients, in silico treatment plans to a total dose of 50.4Gy to the target volume were generated for the four treatment modalities investigated (i.e., IMRT, VMAT, TOMO, IMPT). Resulting treatment plans were analyzed regarding dose to target and surrounding OARs comparing IMRT, TOMO and IMPT to VMAT.Results: In total, 100 treatment plans (four per patient) were analyzed. Compared to VMAT, the IMPT mean dose (D-mean) for nine out of 10 (90%) OARs was statistically significantly (p

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Acta Oncologica
Volume	58
Issue number	1
DOIs	https://doi.org/10.1080/0284186X.2018.1529424
Publication status	Published - 2019

Keywords

HELICAL TOMOTHERAPY
BEAM THERAPY
ARC THERAPY
RADIOTHERAPY
RADIATION
CANCER
HEAD
PHOTONS
IMPACT
RANGE

Access to Document

10.1080/0284186X.2018.1529424Licence: CC BY-NC-ND

Cite this

Eekers, D. B. P., Roelofs, E., Cubillos-Mesias, M., Niel, C., Smeenk, R. J., Hoeben, A., Minken, A. W. H., Granzier, M., Janssens, G. O., Kaanders, J. H. A. M., Lambin, P., & Troost, E. G. C. (2019). Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial. Acta Oncologica, 58(1), 57-65. https://doi.org/10.1080/0284186X.2018.1529424

@article{6ec29a4b1aac474887876064815ed439,

title = "Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial",

abstract = "Background and purpose: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). The aim of this comparative in silico study was to determine these dosimetric differences in delivered doses.Material and methods: Imaging datasets of 25 LGG patients having undergone postoperative radiotherapy were included. For each of these patients, in silico treatment plans to a total dose of 50.4Gy to the target volume were generated for the four treatment modalities investigated (i.e., IMRT, VMAT, TOMO, IMPT). Resulting treatment plans were analyzed regarding dose to target and surrounding OARs comparing IMRT, TOMO and IMPT to VMAT.Results: In total, 100 treatment plans (four per patient) were analyzed. Compared to VMAT, the IMPT mean dose (D-mean) for nine out of 10 (90%) OARs was statistically significantly (p",

keywords = "HELICAL TOMOTHERAPY, BEAM THERAPY, ARC THERAPY, RADIOTHERAPY, RADIATION, CANCER, HEAD, PHOTONS, IMPACT, RANGE",

author = "Eekers, {Danielle B. P.} and Erik Roelofs and Macarena Cubillos-Mesias and Charles Niel and Smeenk, {Robert Jan} and Ann Hoeben and Minken, {Andre W. H.} and Marlies Granzier and Janssens, {Geert O.} and Kaanders, {Johannes H. A. M.} and Philippe Lambin and Troost, {Esther G. C.}",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2019",

doi = "10.1080/0284186X.2018.1529424",

language = "English",

volume = "58",

pages = "57--65",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Routledge/Taylor & Francis Group",

number = "1",

}

Eekers, DBP , Roelofs, E, Cubillos-Mesias, M, Niel, C, Smeenk, RJ, Hoeben, A, Minken, AWH, Granzier, M, Janssens, GO, Kaanders, JHAM, Lambin, P & Troost, EGC 2019, 'Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial', Acta Oncologica, vol. 58, no. 1, pp. 57-65. https://doi.org/10.1080/0284186X.2018.1529424

TY - JOUR

T1 - Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients

T2 - results of a multicentric in silico ROCOCO trial

AU - Eekers, Danielle B. P.

AU - Roelofs, Erik

AU - Cubillos-Mesias, Macarena

AU - Niel, Charles

AU - Smeenk, Robert Jan

AU - Hoeben, Ann

AU - Minken, Andre W. H.

AU - Granzier, Marlies

AU - Janssens, Geert O.

AU - Kaanders, Johannes H. A. M.

AU - Lambin, Philippe

AU - Troost, Esther G. C.

PY - 2019

Y1 - 2019

N2 - Background and purpose: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). The aim of this comparative in silico study was to determine these dosimetric differences in delivered doses.Material and methods: Imaging datasets of 25 LGG patients having undergone postoperative radiotherapy were included. For each of these patients, in silico treatment plans to a total dose of 50.4Gy to the target volume were generated for the four treatment modalities investigated (i.e., IMRT, VMAT, TOMO, IMPT). Resulting treatment plans were analyzed regarding dose to target and surrounding OARs comparing IMRT, TOMO and IMPT to VMAT.Results: In total, 100 treatment plans (four per patient) were analyzed. Compared to VMAT, the IMPT mean dose (D-mean) for nine out of 10 (90%) OARs was statistically significantly (p

AB - Background and purpose: Patients with low-grade glioma (LGG) have a prolonged survival expectancy due to better discriminative tumor classification and multimodal treatment. Consequently, long-term treatment toxicity gains importance. Contemporary radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), tomotherapy (TOMO) and intensity-modulated proton therapy (IMPT) enable high-dose irradiation of the target but they differ regarding delivered dose to organs at risk (OARs). The aim of this comparative in silico study was to determine these dosimetric differences in delivered doses.Material and methods: Imaging datasets of 25 LGG patients having undergone postoperative radiotherapy were included. For each of these patients, in silico treatment plans to a total dose of 50.4Gy to the target volume were generated for the four treatment modalities investigated (i.e., IMRT, VMAT, TOMO, IMPT). Resulting treatment plans were analyzed regarding dose to target and surrounding OARs comparing IMRT, TOMO and IMPT to VMAT.Results: In total, 100 treatment plans (four per patient) were analyzed. Compared to VMAT, the IMPT mean dose (D-mean) for nine out of 10 (90%) OARs was statistically significantly (p

KW - HELICAL TOMOTHERAPY

KW - BEAM THERAPY

KW - ARC THERAPY

KW - RADIOTHERAPY

KW - RADIATION

KW - CANCER

KW - HEAD

KW - PHOTONS

KW - IMPACT

KW - RANGE

U2 - 10.1080/0284186X.2018.1529424

DO - 10.1080/0284186X.2018.1529424

M3 - Article

C2 - 30474448

SN - 0284-186X

VL - 58

SP - 57

EP - 65

JO - Acta Oncologica

JF - Acta Oncologica

IS - 1

ER -