Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study

Lisa Eggebrecht; Juergen H. Prochaska; Andreas Schulz; Natalie Arnold; Claus Juenger; Sebastian Goebel; Dagmar Laubert-Reh; Harald Binder; Manfred E. Beutel; Nobert Pfeiffer; Stefan Blankenberg; Karl J. Lackner; Henri M. Spronk; Hugo ten Cate; Thomas Muenzel; Philipp S. Wild

doi:10.1161/JAHA.118.008650

Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study

Lisa Eggebrecht, Juergen H. Prochaska, Andreas Schulz, Natalie Arnold, Claus Juenger, Sebastian Goebel, Dagmar Laubert-Reh, Harald Binder, Manfred E. Beutel, Nobert Pfeiffer, Stefan Blankenberg, Karl J. Lackner, Henri M. Spronk, Hugo ten Cate, Thomas Muenzel, Philipp S. Wild^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background-Preclinical data have indicated a link between use of vitamin K antagonists (VKA) and detrimental effects on vascular structure and function. The objective of the present study was to determine the relationship between VKA intake and different phenotypes of subclinical cardiovascular disease in the population.

Methods and Results-Clinical and laboratory data, as well as medical-technical examinations were assessed from 15 010 individuals aged 35 to 74 years during a highly standardized 5-hour visit at the study center of the population-based Gutenberg Health Study. In total, the study sample comprised 287 VKA users and 14 564 VKA nonusers. Multivariable analysis revealed an independent association between VKA intake and stiffness index (beta=+2.54 m/s; [0.41/4.66]; P=0.019), ankle-brachial index (beta=-0.03; [- 0.04/-0.01]; P

Conclusions-These data demonstrate negative effects of VKA on vascular and cardiac phenotypes of subclinical cardiovascular disease, indicating a possible influence on long-term disease development. These findings may be clinically relevant for the provision of individually tailored antithrombotic therapy.

Original language	English
Article number	008650
Number of pages	25
Journal	Journal of the American Heart Association
Volume	7
Issue number	17
DOIs	https://doi.org/10.1161/JAHA.118.008650
Publication status	Published - 4 Sept 2018

Keywords

cardiovascular disease
oral anticoagulation
pharmacogenomic variants
vitamin K antagonists
MATRIX GLA-PROTEIN
ORAL ANTICOAGULANT
CALCIFICATION
WARFARIN
PROGRESSION
ARTERIAL
THERAPY
RISK

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Cite this

Eggebrecht, L., Prochaska, J. H., Schulz, A., Arnold, N., Juenger, C., Goebel, S., Laubert-Reh, D., Binder, H., Beutel, M. E., Pfeiffer, N., Blankenberg, S., Lackner, K. J., Spronk, H. M., ten Cate, H., Muenzel, T., & Wild, P. S. (2018). Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study. Journal of the American Heart Association, 7(17), Article 008650. https://doi.org/10.1161/JAHA.118.008650

@article{7d44da1ed63241848dd334cb49c6a062,

title = "Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study",

abstract = "Background-Preclinical data have indicated a link between use of vitamin K antagonists (VKA) and detrimental effects on vascular structure and function. The objective of the present study was to determine the relationship between VKA intake and different phenotypes of subclinical cardiovascular disease in the population.Methods and Results-Clinical and laboratory data, as well as medical-technical examinations were assessed from 15 010 individuals aged 35 to 74 years during a highly standardized 5-hour visit at the study center of the population-based Gutenberg Health Study. In total, the study sample comprised 287 VKA users and 14 564 VKA nonusers. Multivariable analysis revealed an independent association between VKA intake and stiffness index (beta=+2.54 m/s; [0.41/4.66]; P=0.019), ankle-brachial index (beta=-0.03; [- 0.04/-0.01]; PConclusions-These data demonstrate negative effects of VKA on vascular and cardiac phenotypes of subclinical cardiovascular disease, indicating a possible influence on long-term disease development. These findings may be clinically relevant for the provision of individually tailored antithrombotic therapy.",

keywords = "cardiovascular disease, oral anticoagulation, pharmacogenomic variants, vitamin K antagonists, MATRIX GLA-PROTEIN, ORAL ANTICOAGULANT, CALCIFICATION, WARFARIN, PROGRESSION, ARTERIAL, THERAPY, RISK",

author = "Lisa Eggebrecht and Prochaska, {Juergen H.} and Andreas Schulz and Natalie Arnold and Claus Juenger and Sebastian Goebel and Dagmar Laubert-Reh and Harald Binder and Beutel, {Manfred E.} and Nobert Pfeiffer and Stefan Blankenberg and Lackner, {Karl J.} and Spronk, {Henri M.} and {ten Cate}, Hugo and Thomas Muenzel and Wild, {Philipp S.}",

year = "2018",

month = sep,

day = "4",

doi = "10.1161/JAHA.118.008650",

language = "English",

volume = "7",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

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Eggebrecht, L, Prochaska, JH, Schulz, A, Arnold, N, Juenger, C, Goebel, S, Laubert-Reh, D, Binder, H, Beutel, ME, Pfeiffer, N, Blankenberg, S, Lackner, KJ, Spronk, HM , ten Cate, H, Muenzel, T & Wild, PS 2018, 'Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study', Journal of the American Heart Association, vol. 7, no. 17, 008650. https://doi.org/10.1161/JAHA.118.008650

TY - JOUR

T1 - Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease

T2 - Results From the Population-Based Gutenberg Health Study

AU - Eggebrecht, Lisa

AU - Prochaska, Juergen H.

AU - Schulz, Andreas

AU - Arnold, Natalie

AU - Juenger, Claus

AU - Goebel, Sebastian

AU - Laubert-Reh, Dagmar

AU - Binder, Harald

AU - Beutel, Manfred E.

AU - Pfeiffer, Nobert

AU - Blankenberg, Stefan

AU - Lackner, Karl J.

AU - Spronk, Henri M.

AU - ten Cate, Hugo

AU - Muenzel, Thomas

AU - Wild, Philipp S.

PY - 2018/9/4

Y1 - 2018/9/4

N2 - Background-Preclinical data have indicated a link between use of vitamin K antagonists (VKA) and detrimental effects on vascular structure and function. The objective of the present study was to determine the relationship between VKA intake and different phenotypes of subclinical cardiovascular disease in the population.Methods and Results-Clinical and laboratory data, as well as medical-technical examinations were assessed from 15 010 individuals aged 35 to 74 years during a highly standardized 5-hour visit at the study center of the population-based Gutenberg Health Study. In total, the study sample comprised 287 VKA users and 14 564 VKA nonusers. Multivariable analysis revealed an independent association between VKA intake and stiffness index (beta=+2.54 m/s; [0.41/4.66]; P=0.019), ankle-brachial index (beta=-0.03; [- 0.04/-0.01]; PConclusions-These data demonstrate negative effects of VKA on vascular and cardiac phenotypes of subclinical cardiovascular disease, indicating a possible influence on long-term disease development. These findings may be clinically relevant for the provision of individually tailored antithrombotic therapy.

AB - Background-Preclinical data have indicated a link between use of vitamin K antagonists (VKA) and detrimental effects on vascular structure and function. The objective of the present study was to determine the relationship between VKA intake and different phenotypes of subclinical cardiovascular disease in the population.Methods and Results-Clinical and laboratory data, as well as medical-technical examinations were assessed from 15 010 individuals aged 35 to 74 years during a highly standardized 5-hour visit at the study center of the population-based Gutenberg Health Study. In total, the study sample comprised 287 VKA users and 14 564 VKA nonusers. Multivariable analysis revealed an independent association between VKA intake and stiffness index (beta=+2.54 m/s; [0.41/4.66]; P=0.019), ankle-brachial index (beta=-0.03; [- 0.04/-0.01]; PConclusions-These data demonstrate negative effects of VKA on vascular and cardiac phenotypes of subclinical cardiovascular disease, indicating a possible influence on long-term disease development. These findings may be clinically relevant for the provision of individually tailored antithrombotic therapy.

KW - cardiovascular disease

KW - oral anticoagulation

KW - pharmacogenomic variants

KW - vitamin K antagonists

KW - MATRIX GLA-PROTEIN

KW - ORAL ANTICOAGULANT

KW - CALCIFICATION

KW - WARFARIN

KW - PROGRESSION

KW - ARTERIAL

KW - THERAPY

KW - RISK

U2 - 10.1161/JAHA.118.008650

DO - 10.1161/JAHA.118.008650

M3 - Article

SN - 2047-9980

VL - 7

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 17

M1 - 008650

ER -