Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population

S Bonneux; E Fransen; E Van Eyken; L Van Laer; J Huyghe; P Van de Heyning; A Voets; M Gerards; A P M Stassen; A T M Hendrickx; H J M Smeets; G Van Camp

doi:10.1016/j.mito.2011.05.008

Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population

S Bonneux, E Fransen, E Van Eyken, L Van Laer, J Huyghe, P Van de Heyning, A Voets, M Gerards, A P M Stassen, A T M Hendrickx, H J M Smeets, G Van Camp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.

Original language	English
Pages (from-to)	729-734
Number of pages	6
Journal	Mitochondrion
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/j.mito.2011.05.008
Publication status	Published - Sept 2011

Keywords

Aged
Belgium
Genes, Mitochondrial
Genetic Association Studies
Haplotypes
Heredity
Humans
Middle Aged
Mitochondria
Mutation
Phenotype
Polymorphism, Single Nucleotide
Presbycusis
Risk Factors
Sequence Analysis, DNA
Statistics, Nonparametric

Access to Document

10.1016/j.mito.2011.05.008

Cite this

Bonneux, S., Fransen, E., Van Eyken, E., Van Laer, L., Huyghe, J., Van de Heyning, P., Voets, A., Gerards, M., Stassen, A. P. M., Hendrickx, A. T. M., Smeets, H. J. M., & Van Camp, G. (2011). Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population. Mitochondrion, 11(5), 729-734. https://doi.org/10.1016/j.mito.2011.05.008

@article{a50b293a6b5f40179955fffee326f106,

title = "Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population",

abstract = "Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.",

keywords = "Aged, Belgium, Genes, Mitochondrial, Genetic Association Studies, Haplotypes, Heredity, Humans, Middle Aged, Mitochondria, Mutation, Phenotype, Polymorphism, Single Nucleotide, Presbycusis, Risk Factors, Sequence Analysis, DNA, Statistics, Nonparametric",

author = "S Bonneux and E Fransen and {Van Eyken}, E and {Van Laer}, L and J Huyghe and {Van de Heyning}, P and A Voets and M Gerards and Stassen, {A P M} and Hendrickx, {A T M} and Smeets, {H J M} and {Van Camp}, G",

note = "Copyright {\textcopyright} 2011. Published by Elsevier B.V.",

year = "2011",

month = sep,

doi = "10.1016/j.mito.2011.05.008",

language = "English",

volume = "11",

pages = "729--734",

journal = "Mitochondrion",

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Bonneux, S, Fransen, E, Van Eyken, E, Van Laer, L, Huyghe, J, Van de Heyning, P, Voets, A, Gerards, M , Stassen, APM, Hendrickx, ATM, Smeets, HJM & Van Camp, G 2011, 'Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population', Mitochondrion, vol. 11, no. 5, pp. 729-734. https://doi.org/10.1016/j.mito.2011.05.008

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T1 - Inherited mitochondrial variants are not a major cause of age-related hearing impairment in the European population

AU - Bonneux, S

AU - Fransen, E

AU - Van Eyken, E

AU - Van Laer, L

AU - Huyghe, J

AU - Van de Heyning, P

AU - Voets, A

AU - Gerards, M

AU - Stassen, A P M

AU - Hendrickx, A T M

AU - Smeets, H J M

AU - Van Camp, G

PY - 2011/9

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N2 - Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.

AB - Mitochondrial DNA (mtDNA) mutations have been implicated in various age-related diseases. To further clarify the role of mtDNA variants in age-related hearing impairment (ARHI), we determined the DNA sequence of the entire mitochondrial genome of 400 individuals using the Affymetrix Human Mitochondrial Resequencing Array. These were the 200 worst hearing and the 200 best hearing from a collection of 947 Belgian samples. We performed association tests with individual mitochondrial variants, comparison of the mutation load, and association with European haplogroups and their interaction with environmental risk factors. We also tested the influence of rare variants on ARHI. None of these tests showed any association with ARHI.

KW - Aged

KW - Belgium

KW - Genes, Mitochondrial

KW - Genetic Association Studies

KW - Haplotypes

KW - Heredity

KW - Humans

KW - Middle Aged

KW - Mitochondria

KW - Mutation

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Presbycusis

KW - Risk Factors

KW - Sequence Analysis, DNA

KW - Statistics, Nonparametric

U2 - 10.1016/j.mito.2011.05.008

DO - 10.1016/j.mito.2011.05.008

M3 - Article

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SN - 1567-7249

VL - 11

SP - 729

EP - 734

JO - Mitochondrion

JF - Mitochondrion

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ER -