Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk

Yvette Nicole Lowensteyn; Nicolaas Johannes Georgius Jansen; Marc van Heerde; Richard Henryk Klein; Martin Christiaan Jacques Kneyber; Jan Willem Kuiper; Maaike Anne Riedijk; Carin Wilhelmus Maria Verlaat; Idse Hendrik Egbert Visser; Dirk Adriaan van Waardenburg; Peter Marin van Hasselt

doi:10.1007/s00431-019-03391-y

Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk

Yvette Nicole Lowensteyn, Nicolaas Johannes Georgius Jansen, Marc van Heerde, Richard Henryk Klein, Martin Christiaan Jacques Kneyber, Jan Willem Kuiper, Maaike Anne Riedijk, Carin Wilhelmus Maria Verlaat, Idse Hendrik Egbert Visser, Dirk Adriaan van Waardenburg, Peter Marin van Hasselt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150g because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens were compared using both general and targeted surveillance. Late VKDB in the general pediatric population was identified by the Netherlands Pediatric Surveillance Unit, between 1 October 2014 and 31 December 2016. Additionally, infants with intracranial vitamin K deficiency bleeding were identified using the Dutch Pediatric Intensive Care Evaluation registry. The incidence of intracranial VKDB as assessed by general and targeted surveillance decreased from 1.6 per 100,000 (95% CI, 0.4-5.1) to 1.3 per 100,000 (95% CI, 0.5-3.2) and from 3.1 per 100,000 live births (95% CI, 1.9-5.0) to 1.2 per 100,000 live births (95% CI, 0.6-2.3), respectively. Median time between consecutive cases in the latter increased from 24 to 154days (p

Original language	English
Pages (from-to)	1033-1042
Number of pages	10
Journal	European Journal of Pediatrics
Volume	178
Issue number	7
DOIs	https://doi.org/10.1007/s00431-019-03391-y
Publication status	Published - Jul 2019

Keywords

Biliary atresia
Intracranial bleeding
Pediatric intensive care unit
Vitamin K prophylaxis
Vitamin K deficiency bleeding
PREVENTION
REFUSAL
INFANTS
VKDB

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Cite this

Lowensteyn, Y. N., Jansen, N. J. G., van Heerde, M., Klein, R. H., Kneyber, M. C. J., Kuiper, J. W., Riedijk, M. A., Verlaat, C. W. M., Visser, I. H. E., van Waardenburg, D. A., & van Hasselt, P. M. (2019). Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk. European Journal of Pediatrics, 178(7), 1033-1042. https://doi.org/10.1007/s00431-019-03391-y

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abstract = "Vitamin K prophylaxis in infancy aims to prevent life-threatening vitamin K deficiency bleeding (VKDB). The Dutch prophylactic oral daily regimen was increased sixfold from 25 to 150g because of a high failure rate. To evaluate the efficacy of this new regimen, incidences of intracranial VKDB under both regimens were compared using both general and targeted surveillance. Late VKDB in the general pediatric population was identified by the Netherlands Pediatric Surveillance Unit, between 1 October 2014 and 31 December 2016. Additionally, infants with intracranial vitamin K deficiency bleeding were identified using the Dutch Pediatric Intensive Care Evaluation registry. The incidence of intracranial VKDB as assessed by general and targeted surveillance decreased from 1.6 per 100,000 (95% CI, 0.4-5.1) to 1.3 per 100,000 (95% CI, 0.5-3.2) and from 3.1 per 100,000 live births (95% CI, 1.9-5.0) to 1.2 per 100,000 live births (95% CI, 0.6-2.3), respectively. Median time between consecutive cases in the latter increased from 24 to 154days (p",

keywords = "Biliary atresia, Intracranial bleeding, Pediatric intensive care unit, Vitamin K prophylaxis, Vitamin K deficiency bleeding, PREVENTION, REFUSAL, INFANTS, VKDB",

author = "Lowensteyn, {Yvette Nicole} and Jansen, {Nicolaas Johannes Georgius} and {van Heerde}, Marc and Klein, {Richard Henryk} and Kneyber, {Martin Christiaan Jacques} and Kuiper, {Jan Willem} and Riedijk, {Maaike Anne} and Verlaat, {Carin Wilhelmus Maria} and Visser, {Idse Hendrik Egbert} and {van Waardenburg}, {Dirk Adriaan} and {van Hasselt}, {Peter Marin}",

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AU - Kneyber, Martin Christiaan Jacques

AU - Kuiper, Jan Willem

AU - Riedijk, Maaike Anne

AU - Verlaat, Carin Wilhelmus Maria

AU - Visser, Idse Hendrik Egbert

AU - van Waardenburg, Dirk Adriaan

AU - van Hasselt, Peter Marin

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