TY - JOUR
T1 - Increased EEG gamma band activity in Alzheimer's disease and mild cognitive impairment
AU - van Deursen, J.M.
AU - Vuurman, E.F.P.M.
AU - Verhey, F.R.J.
AU - van Kranen-Mastenbroek, V.H.J.M.
AU - Riedel, W.J.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - High frequency (30-70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarker in Alzheimer's disease (AD) and mild cognitive impairment (MCI), 15 psychoactive drug naive AD patients, 20 MCI patients and 20 healthy controls participated in this study. Gamma band power (GBP) was measured in four conditions viz. resting state, music listening, story listening and visual stimulation. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first. The overall TRR was high. Elevated GBP was observed in AD when compared to MCI and control subjects in all conditions. The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls.
AB - High frequency (30-70 Hz) gamma band oscillations in the human electro-encephalogram (EEG) are thought to reflect perceptual and cognitive processes. It is therefore interesting to study these measures in cognitive impairment and dementia. To evaluate gamma band oscillations as a diagnostic biomarker in Alzheimer's disease (AD) and mild cognitive impairment (MCI), 15 psychoactive drug naive AD patients, 20 MCI patients and 20 healthy controls participated in this study. Gamma band power (GBP) was measured in four conditions viz. resting state, music listening, story listening and visual stimulation. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first. The overall TRR was high. Elevated GBP was observed in AD when compared to MCI and control subjects in all conditions. The results suggest that elevated GBP is a reproducible and sensitive measure for cognitive dysfunction in AD in comparison with MCI and controls.
U2 - 10.1007/s00702-008-0083-y
DO - 10.1007/s00702-008-0083-y
M3 - Article
C2 - 18607528
SN - 0300-9564
VL - 115
SP - 1301
EP - 1311
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 9
ER -