Improvement of pulse wave velocity and metabolic cardiovascular risk parameters through egg protein hydrolysate intake: A randomized trial in overweight or obese subjects with impaired glucose tolerance or type 2 diabetes

It was shown in animals that the egg protein-hydrolysate NWT-03 improves endothelial function. We designed a human crossover study to assess acute (2 h) and short-term (2 days) effects of 5 g/d NWT-03 in 40 overweight and obese subjects with impaired glucose-tolerance or type-2 diabetes.

At day 1, both fasting (time point 0;t0) and 120 min after intake (t120), and day 3 (t120), pulse-wave velocity, augmentation index, heart rate and blood pressure were measured and blood was sampled for analysis of metabolic parameters (serum lipids, glucose and insulin). Acute and short-term effects were calculated.

Carotid-radial PWV (short-term), AIx (acute), triacylglycerol (short-term), glucose (acute), and insulin (acute) decreased, while HDL cholesterol (short-term) increased significantly during NWT-03 consumption.

The egg protein-hydrolysate NWT-03 is a potential functional food ingredient in IGT and T2DM. Whether the improvement in cr-PWV is mediated through effects on metabolism as well as long-term benefits warrants further study.