TY - JOUR
T1 - Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling
AU - Bollen, E.
AU - Puzzo, D.
AU - Rutten, K.
AU - Privitera, L.
AU - De Vry, J.
AU - Vanmierlo, T.
AU - Kenis, G.
AU - Palmeri, A.
AU - D'Hooge, R.
AU - Balschun, D.
AU - Steinbusch, H.W.M.
AU - Blokland, A.
AU - Prickaerts, J.
PY - 2014/5/12
Y1 - 2014/5/12
N2 - Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers to the first hours in which labile synaptic changes occur, whereas late consolidation relates to stable and long-lasting synaptic changes induced by de novo protein synthesis. How these phases are linked at a molecular level is not yet clear. Here we studied the interaction of the cyclic nucleotide-mediated pathways during the different phases of memory consolidation in rodents. In addition, the same pathways were studied in a model of neuronal plasticity, long-term potentiation (LTP). We demonstrated that cGMP/PKG signaling mediates early memory consolidation as well as early-phase-LTP, while cAMP/PKA signaling mediates late consolidation and late-phase-like LTP. Additionally, we show for the first time that early-phase cGMP/PKG-signaling requires late-phase cAMP/PKA-signaling in both LTP and long-term memory formation.Neuropsychopharmacology accepted article preview online, 12 May 2014; doi:10.1038/npp.2014.106.
AB - Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers to the first hours in which labile synaptic changes occur, whereas late consolidation relates to stable and long-lasting synaptic changes induced by de novo protein synthesis. How these phases are linked at a molecular level is not yet clear. Here we studied the interaction of the cyclic nucleotide-mediated pathways during the different phases of memory consolidation in rodents. In addition, the same pathways were studied in a model of neuronal plasticity, long-term potentiation (LTP). We demonstrated that cGMP/PKG signaling mediates early memory consolidation as well as early-phase-LTP, while cAMP/PKA signaling mediates late consolidation and late-phase-like LTP. Additionally, we show for the first time that early-phase cGMP/PKG-signaling requires late-phase cAMP/PKA-signaling in both LTP and long-term memory formation.Neuropsychopharmacology accepted article preview online, 12 May 2014; doi:10.1038/npp.2014.106.
U2 - 10.1038/npp.2014.106
DO - 10.1038/npp.2014.106
M3 - Article
C2 - 24813825
SN - 0893-133X
VL - 39
SP - 2497
EP - 2505
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
ER -