Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed

P.M. Peeters; E.F. Wouters; N.L. Reynaert

doi:10.1155/2015/828264

Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed

P.M. Peeters^*, E.F. Wouters, N.L. Reynaert

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis.

Original language	English
Article number	828264
Number of pages	15
Journal	Journal of Immunology Research
Volume	2015
DOIs	https://doi.org/10.1155/2015/828264
Publication status	Published - 1 Jan 2015

Keywords

GAMMA-INDUCING FACTOR
NLRP3 INFLAMMASOME
PULMONARY INFLAMMATION
CIGARETTE-SMOKE
HMGB1 RELEASE
HUMAN KERATINOCYTES
NALP3 INFLAMMASOME
INDUCED ACTIVATION
MESSENGER-RNA
IN-VITRO

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10.1155/2015/828264Licence: CC BY

Cite this

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abstract = "The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis.",

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