Research output

HLA frequencies and associations in cystic fibrosis

Research output: Contribution to journalArticleAcademicpeer-review

Associated researcher

  • Adriaanse, M. P.
  • Vreugdenhil, A.C.E.

  • Groeneweg, M.
  • Bruggenwirth, H. T.
  • Castelijns, S. J.
  • van der Ent, C. K.
  • Voorter, C. E.
  • Tilanus, M. G.

Associated organisations

Abstract

Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.

    Research areas

  • cystic fibrosis, cystic fibrosis transmembrane conductance regulator, HLA antigens, HLA-DQ alpha-chains, HLA-DQ beta-chains, HLA-DRB1 chains, POPULATION, GUIDELINES, DIAGNOSIS, ALLELES, DISEASE, ADULTS
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Details

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalTissue Antigens
Volume83
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014