Abstract
Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.
Original language | English |
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Pages (from-to) | 27-31 |
Number of pages | 5 |
Journal | Tissue Antigens |
Volume | 83 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Keywords
- cystic fibrosis
- cystic fibrosis transmembrane conductance regulator
- HLA antigens
- HLA-DQ alpha-chains
- HLA-DQ beta-chains
- HLA-DRB1 chains
- POPULATION
- GUIDELINES
- DIAGNOSIS
- ALLELES
- DISEASE
- ADULTS