Abstract
Diagnosing acute myocardial infarctions has improved thanks to a highly sensitive method of measuring a cardiac-specific protein (troponin T or I) in the blood. This method also makes it possible to measure troponin levels in healthy individuals. A disadvantage is that elevated troponin levels may be observed in individuals without an infarction as well.
This dissertation found that troponin T exhibits a circadian rhythm in clinically stable individuals with elevated troponin levels. These fluctuations are significant enough to exceed the cut-off value for infarctions. The average clinical relevance is therefore limited and the circadian rhythm may offer an explanation for individual patients whose symptoms do not correspond to the troponin T concentrations. In the case of troponin I, no circadian rhythm was observed.
Troponin may be a valuable mortality predictor in healthy individuals. That said, troponin T has better predictive values than troponin I. In the case of endurance sports, there appears to be a difference between the release of troponin during a myocardial infarction and when practicing an endurance sport.
This dissertation found that troponin T exhibits a circadian rhythm in clinically stable individuals with elevated troponin levels. These fluctuations are significant enough to exceed the cut-off value for infarctions. The average clinical relevance is therefore limited and the circadian rhythm may offer an explanation for individual patients whose symptoms do not correspond to the troponin T concentrations. In the case of troponin I, no circadian rhythm was observed.
Troponin may be a valuable mortality predictor in healthy individuals. That said, troponin T has better predictive values than troponin I. In the case of endurance sports, there appears to be a difference between the release of troponin during a myocardial infarction and when practicing an endurance sport.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 4 Mar 2016 |
Place of Publication | Maastricht |
Publisher | |
Print ISBNs | 9789090295732 |
DOIs | |
Publication status | Published - 2016 |
Keywords
- troponin
- myocardial infarction
- circadian rhythm
- prediction
- endurance sport