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High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T

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@article{bac7cc0d5bea4bff9959496cbc94211b,
title = "High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T",
abstract = "Locus Coeruleus (LC) is a neuromelanin-rich brainstem structure that is the source of noradrenaline in the cortex and is thought to modulate attention and memory. LC imaging in vivo is commonly performed with a 2D T 1-weighted Turbo Spin Echo (TSE) MRI sequence, an approach that suffers from several drawbacks at 3T, including long acquisition times and highly anisotropic spatial resolution. In this study, we developed a high-resolution Magnetization Transfer (MT) sequence for LC imaging at both 7T and 3T and compared its performance to a TSE sequence. Results indicate that LC imaging can be achieved with an MT sequence at both 7 and 3T at higher spatial resolution than the 3T TSE. Furthermore, we investigated whether the currently disputed source of contrast in the LC region with a TSE sequence relates to MT effects or shortened T 1 and T 2* due to increased iron concentration. Our results suggest that the contrast in the LC area relates to MT effects. To conclude, in this study we managed to image the LC, for the first time, at 7T and at an increased resolution compared to the current state-of-the-art. Imaging the LC is highly relevant for clinical diagnostics as structural tissue properties of the LC may hold promise as a biomarker in neurodegenerative diseases.",
keywords = "Locus coeruleus, Magnetization transfer, Neuromelanin, Brainstem, Norepinephrine, 7T, 3T, MRI, PARKINSONS-DISEASE, SUBSTANTIA-NIGRA, ALZHEIMERS-DISEASE, TRANSFER RATIO, NEURONAL VULNERABILITY, NORADRENERGIC SYSTEM, HUMAN BRAIN, NEUROMELANIN, CERULEUS, IRON, Humans, Magnetic Resonance Imaging/methods, Male, Young Adult, Image Processing, Computer-Assisted/methods, Adult, Female, Locus Coeruleus/anatomy & histology, Neuroimaging/methods",
author = "Nikos Priovoulos and Jacobs, {Heidi I.L.} and Dimo Ivanov and Kamil Uludag and Verhey, {Frans R.J.} and Poser, {Benedikt A.}",
note = "Copyright {\circledC} 2018. Published by Elsevier Inc.",
year = "2018",
month = "3",
doi = "10.1016/j.neuroimage.2017.07.045",
language = "English",
volume = "168",
pages = "427--436",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Elsevier Science",

}

RIS

TY - JOUR

T1 - High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T

AU - Priovoulos, Nikos

AU - Jacobs, Heidi I.L.

AU - Ivanov, Dimo

AU - Uludag, Kamil

AU - Verhey, Frans R.J.

AU - Poser, Benedikt A.

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/3

Y1 - 2018/3

N2 - Locus Coeruleus (LC) is a neuromelanin-rich brainstem structure that is the source of noradrenaline in the cortex and is thought to modulate attention and memory. LC imaging in vivo is commonly performed with a 2D T 1-weighted Turbo Spin Echo (TSE) MRI sequence, an approach that suffers from several drawbacks at 3T, including long acquisition times and highly anisotropic spatial resolution. In this study, we developed a high-resolution Magnetization Transfer (MT) sequence for LC imaging at both 7T and 3T and compared its performance to a TSE sequence. Results indicate that LC imaging can be achieved with an MT sequence at both 7 and 3T at higher spatial resolution than the 3T TSE. Furthermore, we investigated whether the currently disputed source of contrast in the LC region with a TSE sequence relates to MT effects or shortened T 1 and T 2* due to increased iron concentration. Our results suggest that the contrast in the LC area relates to MT effects. To conclude, in this study we managed to image the LC, for the first time, at 7T and at an increased resolution compared to the current state-of-the-art. Imaging the LC is highly relevant for clinical diagnostics as structural tissue properties of the LC may hold promise as a biomarker in neurodegenerative diseases.

AB - Locus Coeruleus (LC) is a neuromelanin-rich brainstem structure that is the source of noradrenaline in the cortex and is thought to modulate attention and memory. LC imaging in vivo is commonly performed with a 2D T 1-weighted Turbo Spin Echo (TSE) MRI sequence, an approach that suffers from several drawbacks at 3T, including long acquisition times and highly anisotropic spatial resolution. In this study, we developed a high-resolution Magnetization Transfer (MT) sequence for LC imaging at both 7T and 3T and compared its performance to a TSE sequence. Results indicate that LC imaging can be achieved with an MT sequence at both 7 and 3T at higher spatial resolution than the 3T TSE. Furthermore, we investigated whether the currently disputed source of contrast in the LC region with a TSE sequence relates to MT effects or shortened T 1 and T 2* due to increased iron concentration. Our results suggest that the contrast in the LC area relates to MT effects. To conclude, in this study we managed to image the LC, for the first time, at 7T and at an increased resolution compared to the current state-of-the-art. Imaging the LC is highly relevant for clinical diagnostics as structural tissue properties of the LC may hold promise as a biomarker in neurodegenerative diseases.

KW - Locus coeruleus

KW - Magnetization transfer

KW - Neuromelanin

KW - Brainstem

KW - Norepinephrine

KW - 7T

KW - 3T

KW - MRI

KW - PARKINSONS-DISEASE

KW - SUBSTANTIA-NIGRA

KW - ALZHEIMERS-DISEASE

KW - TRANSFER RATIO

KW - NEURONAL VULNERABILITY

KW - NORADRENERGIC SYSTEM

KW - HUMAN BRAIN

KW - NEUROMELANIN

KW - CERULEUS

KW - IRON

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Young Adult

KW - Image Processing, Computer-Assisted/methods

KW - Adult

KW - Female

KW - Locus Coeruleus/anatomy & histology

KW - Neuroimaging/methods

U2 - 10.1016/j.neuroimage.2017.07.045

DO - 10.1016/j.neuroimage.2017.07.045

M3 - Article

VL - 168

SP - 427

EP - 436

JO - Neuroimage

T2 - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -