TY - JOUR
T1 - High HPA-axis activation disrupts the link between liking and wanting with liking and wanting related brain signaling
AU - Born, J.M.
AU - Martens, M.
AU - Rutters, F.
AU - Lemmens, S.G.
AU - Goebel, R.
AU - Westerterp-Plantenga, M.S.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation. AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions. METHODS: 15 female subjects (21.5+/-0.4years, BMI=22.2+/-0.4) completed fMRI scans on 2days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded. RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate. CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.
AB - BACKGROUND: Eating behavior changes under stress, i.e. during high HPA-axis activation. AIM: Assessment of effects of high versus low HPA-axis activation on liking and wanting related brain signaling in relevant regions. METHODS: 15 female subjects (21.5+/-0.4years, BMI=22.2+/-0.4) completed fMRI scans on 2days, in a fasted as well as a satiated condition on each day. The days were sorted by HPA-axis activation, resulting in two sufficiently separated HPA-axis states which were statistically confirmed (p<.05). During scans, subjects rated liking and wanting for food images; wanting indicated food choice for the subsequent meal. Energy-intake, hunger and fullness were additionally recorded. RESULTS: Hunger changed significantly over the meal (p<.001). Energy intake was lower during the second meal (p<.001). Behavioral wanting was lower after breakfast (p<.01), behavioral liking did not change. During low HPA-activation, liking task related signaling (TRS) pre-meal in the anterior insula predicted behavioral liking, wanting TRS in the anterior insula, nucleus accumbens and thalamus predicted behavioral wanting. During high HPA-activation, these relationships were not present pre-meal, but post-meal behavioral liking was predicted in the nucleus accumbens and wanting in the caudate. CONCLUSION: High HPA-axis activation disrupted and redirected the connection of behavioral liking/wanting with the specifically associated brain signaling in relevant regions.
U2 - 10.1016/j.physbeh.2011.08.015
DO - 10.1016/j.physbeh.2011.08.015
M3 - Article
SN - 0031-9384
VL - 105
SP - 321
EP - 324
JO - Physiology & Behavior
JF - Physiology & Behavior
IS - 2
ER -