Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass

Ervin E. Severdija; Nousjka P. A. Vranken; Antoine P. Simons; Erik D. Gommer; John H. Heijmans; Jos G. Maessen; Patrick W. Weerwind

doi:10.1053/j.jvca.2015.03.022

Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass

Ervin E. Severdija, Nousjka P. A. Vranken^*, Antoine P. Simons, Erik D. Gommer, John H. Heijmans, Jos G. Maessen, Patrick W. Weerwind

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: To investigate the influence of hemodilution and arterial pCO(2) on cerebral autoregulation and cerebral vascular CO2 reactivity. Design: Prospective interventional study. Setting: University hospital-based single-center study. Participants: Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions: Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO(2). Measurements and Main Results: Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit >= 28% or = 28% and

Original language	English
Pages (from-to)	1194-1199
Journal	Journal of Cardiothoracic and Vascular Anesthesia
Volume	29
Issue number	5
DOIs	https://doi.org/10.1053/j.jvca.2015.03.022
Publication status	Published - Oct 2015

Keywords

cardiopulmonary bypass
cerebral autoregulation
cerebral carbon dioxide reactivity
hemodilution

Access to Document

10.1053/j.jvca.2015.03.022

Cite this

@article{237590b30fc3427fa6d698b3ddb25824,

title = "Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass",

abstract = "Objective: To investigate the influence of hemodilution and arterial pCO(2) on cerebral autoregulation and cerebral vascular CO2 reactivity. Design: Prospective interventional study. Setting: University hospital-based single-center study. Participants: Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions: Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO(2). Measurements and Main Results: Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit >= 28% or = 28% and ",

keywords = "cardiopulmonary bypass, cerebral autoregulation, cerebral carbon dioxide reactivity, hemodilution",

author = "Severdija, {Ervin E.} and Vranken, {Nousjka P. A.} and Simons, {Antoine P.} and Gommer, {Erik D.} and Heijmans, {John H.} and Maessen, {Jos G.} and Weerwind, {Patrick W.}",

year = "2015",

month = oct,

doi = "10.1053/j.jvca.2015.03.022",

language = "English",

volume = "29",

pages = "1194--1199",

journal = "Journal of Cardiothoracic and Vascular Anesthesia",

issn = "1053-0770",

publisher = "W B Saunders Co-Elsevier Inc",

number = "5",

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TY - JOUR

T1 - Hemodilution Combined With Hypercapnia Impairs Cerebral Autoregulation During Normothermic Cardiopulmonary Bypass

AU - Severdija, Ervin E.

AU - Vranken, Nousjka P. A.

AU - Simons, Antoine P.

AU - Gommer, Erik D.

AU - Heijmans, John H.

AU - Maessen, Jos G.

AU - Weerwind, Patrick W.

PY - 2015/10

Y1 - 2015/10

N2 - Objective: To investigate the influence of hemodilution and arterial pCO(2) on cerebral autoregulation and cerebral vascular CO2 reactivity. Design: Prospective interventional study. Setting: University hospital-based single-center study. Participants: Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions: Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO(2). Measurements and Main Results: Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit >= 28% or = 28% and

AB - Objective: To investigate the influence of hemodilution and arterial pCO(2) on cerebral autoregulation and cerebral vascular CO2 reactivity. Design: Prospective interventional study. Setting: University hospital-based single-center study. Participants: Forty adult patients undergoing elective cardiac surgery using normothermic cardiopulmonary bypass. Interventions: Blood pressure variations induced by 6/minute metronome-triggered breathing (baseline) and cyclic 6/min changes of indexed pump flow at 3 levels of arterial pCO(2). Measurements and Main Results: Based on median hematocrit on bypass, patients were assigned to either a group of a hematocrit >= 28% or = 28% and

KW - cardiopulmonary bypass

KW - cerebral autoregulation

KW - cerebral carbon dioxide reactivity

KW - hemodilution

U2 - 10.1053/j.jvca.2015.03.022

DO - 10.1053/j.jvca.2015.03.022

M3 - Article

C2 - 26146135

SN - 1053-0770

VL - 29

SP - 1194

EP - 1199

JO - Journal of Cardiothoracic and Vascular Anesthesia

JF - Journal of Cardiothoracic and Vascular Anesthesia

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