Heart failure with preserved ejection fraction: a nephrologist-directed primer

Baris Afsar*, Patrick Rossignol, Loek van Heerebeek, Walter J. Paulus, Kevin Damman, Stephane Heymans, Vanessa van Empel, Alan Sag, Alan Maisel, Mehmet Kanbay

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

There is substantial causal and consequential interaction between the ever-growing heart failure and renal failure patients. Half of the patients with heart failure (HF) have preserved left ventricular ejection fraction (HFpEF), which is difficult to diagnose and rising in prevalence relative to HF with reduced EF (HFpEF). To date, only weight reduction, exercise training, and diuretics have been shown to improve exercise tolerance and morbidity in HFpEF. This review aims to establish the baseline kidney-related concepts specific to the diagnosis and treatment of HFpEF patients and the different aspects of HFpEF and HFpEF in the clinical setting.

Original languageEnglish
Pages (from-to)765-773
Number of pages9
JournalHeart Failure Reviews
Volume22
Issue number6
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Heart failure
  • Chronic kidney disease
  • Preserved ejection fraction
  • Reduced ejection fraction
  • CHRONIC KIDNEY-DISEASE
  • WORSENING RENAL-FUNCTION
  • GLYCATION END-PRODUCTS
  • ENDOTHELIAL DYSFUNCTION
  • NITRIC-OXIDE
  • PROGNOSTIC-SIGNIFICANCE
  • VASCULAR FUNCTION
  • OXIDATIVE STRESS
  • GALECTIN-3
  • OUTCOMES

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