Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Martin Lacko; Boudewijn J. M. Braakhuis; Erich M. Sturgis; Carsten C. Boedeker; Carlos Suarez; Alessandra Rinaldo; Alfio Ferlito; Robert P. Takes

doi:10.1016/j.ijrobp.2013.09.034

Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

Martin Lacko, Boudewijn J. M. Braakhuis, Erich M. Sturgis, Carsten C. Boedeker, Carlos Suarez, Alessandra Rinaldo, Alfio Ferlito, Robert P. Takes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.

Original language	English
Pages (from-to)	38-48
Journal	International Journal of Radiation Oncology Biology Physics
Volume	89
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2013.09.034
Publication status	Published - 1 May 2014

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10.1016/j.ijrobp.2013.09.034

Cite this

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title = "Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma",

abstract = "Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed. ",

author = "Martin Lacko and Braakhuis, {Boudewijn J. M.} and Sturgis, {Erich M.} and Boedeker, {Carsten C.} and Carlos Suarez and Alessandra Rinaldo and Alfio Ferlito and Takes, {Robert P.}",

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T1 - Genetic Susceptibility to Head and Neck Squamous Cell Carcinoma

AU - Lacko, Martin

AU - Braakhuis, Boudewijn J. M.

AU - Sturgis, Erich M.

AU - Boedeker, Carsten C.

AU - Suarez, Carlos

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

AU - Takes, Robert P.

PY - 2014/5/1

Y1 - 2014/5/1

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AB - Head-and-neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, and its incidence is growing. Although environmental carcinogens and carcinogenic viruses are the main etiologic factors, genetic predisposition obviously plays a risk-modulating role, given that not all individuals exposed to these carcinogens experience the disease. This review highlights some aspects of genetic susceptibility to HNSCC: among others, genetic polymorphisms in biotransformation enzymes, DNA repair pathway, apoptotic pathway, human papillomavirus-related pathways, mitochondrial polymorphisms, and polymorphism related to the bilirubin-metabolized pathway. Furthermore, epigenetic variations, familial forms of HNSCC, functional assays for HNSCC risk assessment, and the implications and perspectives of research on genetic susceptibility in HNSCC are discussed.

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DO - 10.1016/j.ijrobp.2013.09.034

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SN - 0360-3016

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