Abstract
BACKGROUND: Interindividual differences in response to weight loss and maintenance thereafter are ascribed to genetic predisposition and behavioral changes. OBJECTIVE: To examine whether body weight and short and long-term body weight loss were affected by candidate single nucleotide polymorphisms (SNPs) and changes in eating behavior or by an interaction between these genetic and behavioral factors. METHODS: 150 healthy subjects (39 males, 111 females) aged 20-50y with a BMI of 27-38kg/m2 followed a very low energy diet for 8-weeks, followed by a 3-month weight maintenance period. SNPs were selected from six candidate genes: ADRB2, FTO, MC4R, PPARG, PPARD, and PPARGC1A. Changes in eating behavior were determined with the Three Factor Eating Questionnaire. RESULTS: A high genetic predisposition score was associated with a high body weight at baseline and more short-term weight loss. From the six selected obesity-related SNPs, FTO was associated with increased body weight at baseline, and the effect allele of PPARGC1A was positively associated with short-term weight loss, when assessed for each SNP separately. Long-term weight loss was associated with a larger increase in dietary restraint and larger decrease in disinhibition. CONCLUSION: During long-term weight loss, genetic effects are dominated by changes in eating behavior.
Original language | English |
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Pages (from-to) | 247-251 |
Number of pages | 5 |
Journal | Physiology & Behavior |
Volume | 128 |
DOIs | |
Publication status | Published - 10 Apr 2014 |
Keywords
- Single nucleotide polymorphism
- Weight loss
- Dietary restraint
- Disinhibition
- FINNISH DIABETES PREVENTION
- BODY-FAT DISTRIBUTION
- ENERGY-EXPENDITURE
- OBESITY
- MAINTENANCE
- POLYMORPHISMS
- ASSOCIATION
- WOMEN
- RECEPTOR
- TRAITS