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Frequency-specific attentional modulation in human primary auditory cortex and midbrain

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Abstract

Paying selective attention to an audio frequency selectively enhances activity within primary auditory cortex (PAC) at the tonotopic site (frequency channel) representing that frequency. Animal PAC neurons achieve this 'frequency-specific attentional spotlight' by adapting their frequency tuning, yet comparable evidence in humans is scarce. Moreover, whether the spotlight operates in human midbrain is unknown. To address these issues, we studied the spectral tuning of frequency channels in human PAC and inferior colliculus (IC), using 7-T functional magnetic resonance imaging (FMRI) and frequency mapping, while participants focused on different frequency-specific sounds. We found that shifts in frequency-specific attention alter the response gain, but not tuning profile, of PAC frequency channels. The gain modulation was strongest in low-frequency channels and varied near-monotonically across the tonotopic axis, giving rise to the attentional spotlight. We observed less prominent, non-tonotopic spatial patterns of attentional modulation in IC. These results indicate that the frequency-specific attentional spotlight in human PAC as measured with FMRI arises primarily from tonotopic gain modulation, rather than adapted frequency tuning. Moreover, frequency-specific attentional modulation of afferent sound processing in human IC seems to be considerably weaker, suggesting that the spotlight diminishes toward this lower-order processing stage. Our study sheds light on how the human auditory pathway adapts to the different demands of selective hearing.

    Research areas

  • Journal Article, CORTICOFUGAL MODULATION, Human primary auditory cortex, SUPERIOR TEMPORAL GYRUS, Human inferior colliculus, Auditory attention, SELECTIVE ATTENTION, FMRI ACTIVATION, BRAIN-STEM, SPATIAL ATTENTION, TASK-RELATED PLASTICITY, INFERIOR COLLICULUS, SPECTROTEMPORAL RECEPTIVE-FIELDS, Frequency tuning, VISUAL-ATTENTION, FMRI, Humans, Male, Inferior Colliculi/physiology, Young Adult, Adult, Female, Acoustic Stimulation, Auditory Perception/physiology, Auditory Pathways/physiology, Auditory Cortex/physiology, Magnetic Resonance Imaging, Brain Mapping, Attention/physiology
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Details

Original languageEnglish
Pages (from-to)274-287
Number of pages14
JournalNeuroimage
Volume174
DOIs
Publication statusPublished - 1 Jul 2018