TY - JOUR
T1 - Focal application of accelerated iTBS results in global changes in graph measures
AU - Klooster, Deborah C. W.
AU - Franklin, Suzanne L.
AU - Besseling, Rene M. H.
AU - Jansen, Jaap F. A.
AU - Caeyenberghs, Karen
AU - Duprat, Romain
AU - Aldenkamp, Albert P.
AU - de Louw, Anton J. A.
AU - Boon, Paul A. J. M.
AU - Baeken, Chris
N1 - Funding Information:
This work was also supported by the Ghent University Multidisciplinary Research Partnership, “The integrative neuroscience of behavioral control”, and a grant of the “Fonds Wetenschappelijk Onderzoek Rode Neuzen” (G0F4617N).
Publisher Copyright:
© 2018 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.
AB - Graph analysis was used to study the effects of accelerated intermittent theta burst stimulation (aiTBS) on the brain's network topology in medication-resistant depressed patients. Anatomical and resting-state functional MRI (rs-fMRI) was recorded at baseline and after sham and verum stimulation. Depression severity was assessed using the Hamilton Depression Rating Scale (HDRS). Using various graph measures, the different effects of sham and verum aiTBS were calculated. It was also investigated whether changes in graph measures were correlated to clinical responses. Furthermore, by correlating baseline graph measures with the changes in HDRS in terms of percentage, the potential of graph measures as biomarker was studied. Although no differences were observed between the effects of verum and sham stimulation on whole-brain graph measures and changes in graph measures did not correlate with clinical response, the baseline values of clustering coefficient and global efficiency showed to be predictive of the clinical response to verum aiTBS. Nodal effects were found throughout the whole brain. The distribution of these effects could not be linked to the strength of the functional connectivity between the stimulation site and the node. This study showed that the effects of aiTBS on graph measures distribute beyond the actual stimulation site. However, additional research into the complex interactions between different areas in the brain is necessary to understand the effects of aiTBS in more detail.
KW - accelerated intermittent theta burst stimulation
KW - functional connectivity
KW - graph analysis
KW - transcranial magnetic stimulation
KW - TRANSCRANIAL MAGNETIC STIMULATION
KW - THETA-BURST STIMULATION
KW - MAJOR DEPRESSIVE DISORDER
KW - LATE-LIFE DEPRESSION
KW - DORSOLATERAL PREFRONTAL CORTEX
KW - HF-RTMS TREATMENT
KW - FUNCTIONAL CONNECTIVITY
KW - ORBITOFRONTAL CORTEX
KW - STRUCTURAL NETWORKS
KW - DEFAULT MODE
U2 - 10.1002/hbm.24384
DO - 10.1002/hbm.24384
M3 - Article
C2 - 30273448
SN - 1065-9471
VL - 40
SP - 432
EP - 450
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 2
ER -