Abstract
BACKGROUND AND PURPOSE: Previously, we showed a good correlation between pathology and an automatically generated PET-contour in rectal cancer. This study analyzed the effect of the use of PET-CT scan on the interobserver variation in GTV definition in rectal cancer and the influence of PET-CT on treatment volumes. MATERIALS AND METHODS: Forty two patients diagnosed with rectal cancer underwent an FDG-PET-CT for radiotherapy planning. An automatic contour was created on PET-scan using the source-to-background ratio. The GTV was delineated by 5 observers in 3 rounds: using CT and MRI, using CT, MRI and PET and using CT, MRI and PET auto-contour. GTV volumes were compared and concordance indices (CI) were calculated. Since the GTV is only a small portion of the treatment volume in rectal cancer, a separate analysis was performed to evaluate the influence of PET on the definition of the CTV used in daily clinical practice and the caudal extension of the treatment volumes. RESULTS: GTV volumes based on PET were significantly smaller. CIs increased significantly using PET and the best interobserver agreement was observed using PET auto-contours. Furthermore, we found that in up to 29% of patients the CTV based on PET extended outside the CTV used in clinical practice. The caudal border of the treatment volume can be tailored using PET-scan in low seated tumors. Influence of PET on the position of the caudal border was most pronounced in high seated tumors. CONCLUSION: PET-CT increases the interobserver agreement in the GTV definition in rectal cancer, helps to avoid geographical misses and allows tailoring the caudal border of the treatment volume.
Original language | English |
---|---|
Pages (from-to) | 371-376 |
Number of pages | 6 |
Journal | Radiotherapy and Oncology |
Volume | 102 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2012 |
Keywords
- Rectal cancer
- PET-CT
- Contouring
- Interobserver variation
- Automatic contouring
- COURSE PREOPERATIVE RADIOTHERAPY
- PATHOLOGICAL COMPLETE RESPONSE
- TARGET VOLUME DELINEATION
- TOTAL MESORECTAL EXCISION
- CELL LUNG-CANCER
- QUALITY-OF-LIFE
- CONFORMAL RADIOTHERAPY
- COLORECTAL-CANCER
- RESECTION MARGIN
- DOSE-ESCALATION