Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation

Yvonne M. J. Goertz; Martijn A. Spruit; Alex J. Van't Hul; Jeannette B. Peters; Maarten Van Herck; Nienke Nakken; Remco S. Djamin; Chris Burtin; Melissa S. Y. Thong; Arnold Coors; Yvonne Meertens-Kerris; Emiel F. M. Wouters; Judith B. Prins; Frits M. E. Franssen; Jean W. M. Muris; Lowie E. G. W. Vanfleteren; Mirjam A. G. Sprangers; Daisy J. A. Janssen; Jan H. Vercoulen

doi:10.1177/1753466619878128

Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation

Yvonne M. J. Goertz^*, Martijn A. Spruit, Alex J. Van't Hul, Jeannette B. Peters, Maarten Van Herck, Nienke Nakken, Remco S. Djamin, Chris Burtin, Melissa S. Y. Thong, Arnold Coors, Yvonne Meertens-Kerris, Emiel F. M. Wouters, Judith B. Prins, Frits M. E. Franssen, Jean W. M. Muris, Lowie E. G. W. Vanfleteren, Mirjam A. G. Sprangers, Daisy J. A. Janssen, Jan H. Vercoulen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity. Methods: A total of 1290 patients with COPD [age 65 +/- 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 +/- 19% predicted] and 199 subjects without COPD (age 63 +/- 9 years, 51% male, FEV1 112 +/- 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity. Results: Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 +/- 12 versus 21 +/- 11 points, p <0.001; 49 versus 10%, p <0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient=-0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables. Conclusions: Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.

Original language	English
Article number	1753466619878128
Number of pages	13
Journal	Therapeutic Advances in Respiratory Disease
Volume	13
DOIs	https://doi.org/10.1177/1753466619878128
Publication status	Published - Sept 2019

Keywords

airway obstruction
chronic obstructive pulmonary disease
fatigue
OBSTRUCTIVE PULMONARY-DISEASE
QUALITY-OF-LIFE
HEALTH-STATUS
SYSTEMIC INFLAMMATION
SUBJECTIVE FATIGUE
PHYSICAL-ACTIVITY
POPULATION
SYMPTOMS
DEPRESSION
IMPACT

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Goertz, Y. M. J., Spruit, M. A., Van't Hul, A. J., Peters, J. B., Van Herck, M., Nakken, N., Djamin, R. S., Burtin, C., Thong, M. S. Y., Coors, A., Meertens-Kerris, Y., Wouters, E. F. M., Prins, J. B., Franssen, F. M. E., Muris, J. W. M., Vanfleteren, L. E. G. W., Sprangers, M. A. G., Janssen, D. J. A., & Vercoulen, J. H. (2019). Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation. Therapeutic Advances in Respiratory Disease, 13, Article 1753466619878128. https://doi.org/10.1177/1753466619878128

@article{22556f8ae71c4d3ebc16c6c911faf535,

title = "Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation",

abstract = "Background: The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity. Methods: A total of 1290 patients with COPD [age 65 +/- 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 +/- 19% predicted] and 199 subjects without COPD (age 63 +/- 9 years, 51% male, FEV1 112 +/- 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity. Results: Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 +/- 12 versus 21 +/- 11 points, p <0.001; 49 versus 10%, p <0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient=-0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables. Conclusions: Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.",

keywords = "airway obstruction, chronic obstructive pulmonary disease, fatigue, OBSTRUCTIVE PULMONARY-DISEASE, QUALITY-OF-LIFE, HEALTH-STATUS, SYSTEMIC INFLAMMATION, SUBJECTIVE FATIGUE, PHYSICAL-ACTIVITY, POPULATION, SYMPTOMS, DEPRESSION, IMPACT",

author = "Goertz, {Yvonne M. J.} and Spruit, {Martijn A.} and {Van't Hul}, {Alex J.} and Peters, {Jeannette B.} and {Van Herck}, Maarten and Nienke Nakken and Djamin, {Remco S.} and Chris Burtin and Thong, {Melissa S. Y.} and Arnold Coors and Yvonne Meertens-Kerris and Wouters, {Emiel F. M.} and Prins, {Judith B.} and Franssen, {Frits M. E.} and Muris, {Jean W. M.} and Vanfleteren, {Lowie E. G. W.} and Sprangers, {Mirjam A. G.} and Janssen, {Daisy J. A.} and Vercoulen, {Jan H.}",

note = "Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and publication of this article: This project is supported by the Lung foundation Netherlands, Leusden, the Netherlands (grant numbers 4.1.16.085 and 3.4.12.024); AstraZeneca, the Netherlands; Boehringer Ingelheim, the Netherlands; Stichting Astma Bestrijding, the Netherlands; Hasselt University, Belgium; and CIRO, the Netherlands. Publisher Copyright: {\textcopyright} The Author(s), 2019.",

year = "2019",

month = sep,

doi = "10.1177/1753466619878128",

language = "English",

volume = "13",

journal = "Therapeutic Advances in Respiratory Disease",

issn = "1753-4658",

publisher = "SAGE Publications Ltd",

}

Goertz, YMJ , Spruit, MA, Van't Hul, AJ, Peters, JB, Van Herck, M, Nakken, N, Djamin, RS, Burtin, C, Thong, MSY, Coors, A, Meertens-Kerris, Y, Wouters, EFM, Prins, JB, Franssen, FME , Muris, JWM , Vanfleteren, LEGW, Sprangers, MAG, Janssen, DJA & Vercoulen, JH 2019, 'Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation', Therapeutic Advances in Respiratory Disease, vol. 13, 1753466619878128. https://doi.org/10.1177/1753466619878128

TY - JOUR

T1 - Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation

AU - Goertz, Yvonne M. J.

AU - Spruit, Martijn A.

AU - Van't Hul, Alex J.

AU - Peters, Jeannette B.

AU - Van Herck, Maarten

AU - Nakken, Nienke

AU - Djamin, Remco S.

AU - Burtin, Chris

AU - Thong, Melissa S. Y.

AU - Coors, Arnold

AU - Meertens-Kerris, Yvonne

AU - Wouters, Emiel F. M.

AU - Prins, Judith B.

AU - Franssen, Frits M. E.

AU - Muris, Jean W. M.

AU - Vanfleteren, Lowie E. G. W.

AU - Sprangers, Mirjam A. G.

AU - Janssen, Daisy J. A.

AU - Vercoulen, Jan H.

N1 - Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and publication of this article: This project is supported by the Lung foundation Netherlands, Leusden, the Netherlands (grant numbers 4.1.16.085 and 3.4.12.024); AstraZeneca, the Netherlands; Boehringer Ingelheim, the Netherlands; Stichting Astma Bestrijding, the Netherlands; Hasselt University, Belgium; and CIRO, the Netherlands. Publisher Copyright: © The Author(s), 2019.

PY - 2019/9

Y1 - 2019/9

N2 - Background: The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity. Methods: A total of 1290 patients with COPD [age 65 +/- 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 +/- 19% predicted] and 199 subjects without COPD (age 63 +/- 9 years, 51% male, FEV1 112 +/- 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity. Results: Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 +/- 12 versus 21 +/- 11 points, p <0.001; 49 versus 10%, p <0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient=-0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables. Conclusions: Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.

AB - Background: The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity. Methods: A total of 1290 patients with COPD [age 65 +/- 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 +/- 19% predicted] and 199 subjects without COPD (age 63 +/- 9 years, 51% male, FEV1 112 +/- 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity. Results: Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 +/- 12 versus 21 +/- 11 points, p <0.001; 49 versus 10%, p <0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient=-0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables. Conclusions: Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.

KW - airway obstruction

KW - chronic obstructive pulmonary disease

KW - fatigue

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - QUALITY-OF-LIFE

KW - HEALTH-STATUS

KW - SYSTEMIC INFLAMMATION

KW - SUBJECTIVE FATIGUE

KW - PHYSICAL-ACTIVITY

KW - POPULATION

KW - SYMPTOMS

KW - DEPRESSION

KW - IMPACT

U2 - 10.1177/1753466619878128

DO - 10.1177/1753466619878128

M3 - Article

C2 - 31558115

SN - 1753-4658

VL - 13

JO - Therapeutic Advances in Respiratory Disease

JF - Therapeutic Advances in Respiratory Disease

M1 - 1753466619878128

ER -