TY - JOUR
T1 - Factors associated with patient-reported cosmetic outcome in the Young Boost Breast Trial
AU - Brouwers, Patricia J. A. M.
AU - van Werkhoven, Erik
AU - Bartelink, Harry
AU - Fourquet, Alain
AU - Lemanski, Claire
AU - van Loon, Judith
AU - Maduro, John H.
AU - Russell, Nicola S.
AU - Scheijmans, Luc J. E. E.
AU - Schinagl, Dominic A. X.
AU - Westenberg, Antonia H.
AU - Poortmans, Philip
AU - Boersma, Liesbeth J.
PY - 2016/7
Y1 - 2016/7
N2 - Purpose: To investigate which factors are related to patient reported cosmetic outcome (PRCO) after breast conserving therapy. Methods: From 2004 to 2011, 2421 cT1-2N0-2a breast cancer patients were randomised in the Young Boost Trial between a 16 and a 26 Gy boost to the tumour bed. Cosmesis was scored subjectively by the patient and physician, and objectively using BCCT.core, at baseline, one and four years after treatment. Presence of fibrosis, QoL and rib pain at four years were also scored. Data were complete for 864 patients. The relation between the separate components was investigated using a proportional odds model. Results: Of the 7 BCCT.core parameters, the distance from nipple to inframammary fold and the length of the breast contour were significantly related to the overall PRCO at four years. Patients with more fibrosis and poorer QoL scored their cosmesis worse, while rib pain was not related. The agreement between the different scores was low (kappa 0.26-0.42). Conclusion: The distance from nipple to inframammary fold, the length of the breast contour and the severity of fibrosis were the main factors related to patient-reported cosmetic outcome. Patients with better QoL scored their cosmesis better.
AB - Purpose: To investigate which factors are related to patient reported cosmetic outcome (PRCO) after breast conserving therapy. Methods: From 2004 to 2011, 2421 cT1-2N0-2a breast cancer patients were randomised in the Young Boost Trial between a 16 and a 26 Gy boost to the tumour bed. Cosmesis was scored subjectively by the patient and physician, and objectively using BCCT.core, at baseline, one and four years after treatment. Presence of fibrosis, QoL and rib pain at four years were also scored. Data were complete for 864 patients. The relation between the separate components was investigated using a proportional odds model. Results: Of the 7 BCCT.core parameters, the distance from nipple to inframammary fold and the length of the breast contour were significantly related to the overall PRCO at four years. Patients with more fibrosis and poorer QoL scored their cosmesis worse, while rib pain was not related. The agreement between the different scores was low (kappa 0.26-0.42). Conclusion: The distance from nipple to inframammary fold, the length of the breast contour and the severity of fibrosis were the main factors related to patient-reported cosmetic outcome. Patients with better QoL scored their cosmesis better.
KW - Breast conserving therapy
KW - Cosmetic outcome
KW - Patient reported outcome
KW - Young patients
KW - Young boost trial
U2 - 10.1016/j.radonc.2016.04.017
DO - 10.1016/j.radonc.2016.04.017
M3 - Article
C2 - 27247055
SN - 0167-8140
VL - 120
SP - 107
EP - 113
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 1
ER -