Abstract
The purpose of the present study was to develop gefitinib-loaded polymeric foams that can be used as coating of drug-eluting stents for palliative treatment of bronchotracheal cancer. Release of such an anticancer drug from such stent coating can retard tumor regrowth into the bronchial lumen. Gefitinib-loaded polyurethane (PU) foams were prepared by embedding either gefitinib micronized crystals or gefitinib-loaded poly(lactic-co-glycolic acid) microspheres in water-blown films, with up to 10% w/w loading for gefitinib microcrystals and 15% w/w for gefitinib microspheres (corresponding to 1.0% w/w drug loading). Drug-release studies showed sustained release of gefitinib over a period of nine months, with higher absolute release rates at higher drug loading content. By the end of the studied nine month release periods, 60-100% of the loaded gefitinib had been released. Foams loaded with gefitinib-PLGA microspheres at 15% w/w showed accelerated drug release after 4 months, coinciding with the degradation of PLGA microparticles in the PU foam as demonstrated by scanning electron microscopy (SEM). When applied on a nitinol braided bronchotrachial stent, PU coatings with gefitinib microspheres showed similar mechanical properties as the drug-free PU coating, which indicated that the loading of microspheres did not affect the mechnical properties of the PU foams. In conclusion, we have fabricated drug-loaded PU foams that are suitable for bronchotracheal stent coating.
Original language | English |
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Pages (from-to) | 803-811 |
Number of pages | 9 |
Journal | International Journal of Pharmaceutics |
Volume | 548 |
Issue number | 2 |
DOIs | |
Publication status | Published - 15 Sept 2018 |
Event | 10th European Workshop on Particulate Systems - Department of Pharmacy, Copenhagen, Denmark Duration: 19 Jan 2017 → 20 Jan 2017 |
Keywords
- Gefitinib
- Polyurethane (PU) foams
- Drug-eluting stent
- Polymeric microspheres
- Bronchotracheal cancer
- Controlled release
- CENTRAL AIRWAY-OBSTRUCTION
- LUNG-CANCER
- DELIVERY
- MICROSPHERES
- BEHAVIOR