Extracapsular extension in the positive sentinel lymph node: a marker of poor prognosis in cT1-2N0 breast cancer patients?

Marissa L. G. Vane; Maria A. Willemsen; Lori M. van Roozendaal; Sander M. J. van Kuijk; Loes F. S. Kooreman; Sabine Siesling; Hans H. W. de Wilt; Marjolein L. Smidt

doi:10.1007/s10549-018-05074-y

Extracapsular extension in the positive sentinel lymph node: a marker of poor prognosis in cT1-2N0 breast cancer patients?

Marissa L. G. Vane^*, Maria A. Willemsen, Lori M. van Roozendaal, Sander M. J. van Kuijk, Loes F. S. Kooreman, Sabine Siesling, Hans H. W. de Wilt, Marjolein L. Smidt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ObjectiveThis study aims to evaluate whether extracapsular extension (ECE) in the sentinel lymph node (SLN) is associated with involvement of 4 lymph node metastases at completion axillary lymph node dissection (ALND) and the effect on 5-year disease-free survival (DFS) and 10-year overall survival (OS).Summary background dataECE in a SLN is usually a contraindication for omitting completion ALND in cT1-2N0 breast cancer patients treated with breast-conserving therapy and 1-2 positive SLN(s).MethodsAll cT1-2N0 breast cancer patients with 1-3 positive SLN(s) who underwent ALND between 2005 and 2008 were selected from the Netherlands Cancer Registry. Logistic regression analysis was used to determine the association between ECE and 4 lymph node metastases. Five-year DFS and 10-year OS were analyzed using Kaplan-Meier survival analysis. Cox regression analysis was performed to correct for other prognostic factors.ResultsA total of 3502 patients were included. Information on ECE was available for 2111 (60.3%) patients, consisting of 741 (35.1%) patients with and 1370 (64.9%) without ECE. The incidence of 4 lymph node metastases was 116 (15.7%) in the ECE group vs. 80 (5.8%) in the group without ECE (p

Original language	English
Pages (from-to)	711-718
Number of pages	8
Journal	Breast Cancer Research and Treatment
Volume	174
Issue number	3
DOIs	https://doi.org/10.1007/s10549-018-05074-y
Publication status	Published - Apr 2019

Keywords

Breast cancer
Sentinel lymph node
Axillary lymph node dissection
Extracapsular extension
Disease-free survival
Overall survival
AXILLARY DISSECTION
METASTASIS
INVASION
TRIAL
PREDICTOR
WOMEN

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10.1007/s10549-018-05074-y

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Vane, M. L. G., Willemsen, M. A., van Roozendaal, L. M., van Kuijk, S. M. J., Kooreman, L. F. S., Siesling, S., de Wilt, H. H. W., & Smidt, M. L. (2019). Extracapsular extension in the positive sentinel lymph node: a marker of poor prognosis in cT1-2N0 breast cancer patients? Breast Cancer Research and Treatment, 174(3), 711-718. https://doi.org/10.1007/s10549-018-05074-y

@article{c37f10d39e1348d594eef786c7d6137c,

title = "Extracapsular extension in the positive sentinel lymph node: a marker of poor prognosis in cT1-2N0 breast cancer patients?",

abstract = "ObjectiveThis study aims to evaluate whether extracapsular extension (ECE) in the sentinel lymph node (SLN) is associated with involvement of 4 lymph node metastases at completion axillary lymph node dissection (ALND) and the effect on 5-year disease-free survival (DFS) and 10-year overall survival (OS).Summary background dataECE in a SLN is usually a contraindication for omitting completion ALND in cT1-2N0 breast cancer patients treated with breast-conserving therapy and 1-2 positive SLN(s).MethodsAll cT1-2N0 breast cancer patients with 1-3 positive SLN(s) who underwent ALND between 2005 and 2008 were selected from the Netherlands Cancer Registry. Logistic regression analysis was used to determine the association between ECE and 4 lymph node metastases. Five-year DFS and 10-year OS were analyzed using Kaplan-Meier survival analysis. Cox regression analysis was performed to correct for other prognostic factors.ResultsA total of 3502 patients were included. Information on ECE was available for 2111 (60.3%) patients, consisting of 741 (35.1%) patients with and 1370 (64.9%) without ECE. The incidence of 4 lymph node metastases was 116 (15.7%) in the ECE group vs. 80 (5.8%) in the group without ECE (p",

keywords = "Breast cancer, Sentinel lymph node, Axillary lymph node dissection, Extracapsular extension, Disease-free survival, Overall survival, AXILLARY DISSECTION, METASTASIS, INVASION, TRIAL, PREDICTOR, WOMEN",

author = "Vane, {Marissa L. G.} and Willemsen, {Maria A.} and {van Roozendaal}, {Lori M.} and {van Kuijk}, {Sander M. J.} and Kooreman, {Loes F. S.} and Sabine Siesling and {de Wilt}, {Hans H. W.} and Smidt, {Marjolein L.}",

note = "Funding Information: The authors thank the Netherlands Cancer Registry and Pathological Anatomical National Automated Archive for providing the clinical and histopathological data. Publisher Copyright: {\textcopyright} 2019, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2019",

month = apr,

doi = "10.1007/s10549-018-05074-y",

language = "English",

volume = "174",

pages = "711--718",

journal = "Breast Cancer Research and Treatment",

issn = "0167-6806",

publisher = "Springer, Cham",

number = "3",

}

TY - JOUR

T1 - Extracapsular extension in the positive sentinel lymph node

T2 - a marker of poor prognosis in cT1-2N0 breast cancer patients?

AU - Vane, Marissa L. G.

AU - Willemsen, Maria A.

AU - van Roozendaal, Lori M.

AU - van Kuijk, Sander M. J.

AU - Kooreman, Loes F. S.

AU - Siesling, Sabine

AU - de Wilt, Hans H. W.

AU - Smidt, Marjolein L.

N1 - Funding Information: The authors thank the Netherlands Cancer Registry and Pathological Anatomical National Automated Archive for providing the clinical and histopathological data. Publisher Copyright: © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/4

Y1 - 2019/4

N2 - ObjectiveThis study aims to evaluate whether extracapsular extension (ECE) in the sentinel lymph node (SLN) is associated with involvement of 4 lymph node metastases at completion axillary lymph node dissection (ALND) and the effect on 5-year disease-free survival (DFS) and 10-year overall survival (OS).Summary background dataECE in a SLN is usually a contraindication for omitting completion ALND in cT1-2N0 breast cancer patients treated with breast-conserving therapy and 1-2 positive SLN(s).MethodsAll cT1-2N0 breast cancer patients with 1-3 positive SLN(s) who underwent ALND between 2005 and 2008 were selected from the Netherlands Cancer Registry. Logistic regression analysis was used to determine the association between ECE and 4 lymph node metastases. Five-year DFS and 10-year OS were analyzed using Kaplan-Meier survival analysis. Cox regression analysis was performed to correct for other prognostic factors.ResultsA total of 3502 patients were included. Information on ECE was available for 2111 (60.3%) patients, consisting of 741 (35.1%) patients with and 1370 (64.9%) without ECE. The incidence of 4 lymph node metastases was 116 (15.7%) in the ECE group vs. 80 (5.8%) in the group without ECE (p

AB - ObjectiveThis study aims to evaluate whether extracapsular extension (ECE) in the sentinel lymph node (SLN) is associated with involvement of 4 lymph node metastases at completion axillary lymph node dissection (ALND) and the effect on 5-year disease-free survival (DFS) and 10-year overall survival (OS).Summary background dataECE in a SLN is usually a contraindication for omitting completion ALND in cT1-2N0 breast cancer patients treated with breast-conserving therapy and 1-2 positive SLN(s).MethodsAll cT1-2N0 breast cancer patients with 1-3 positive SLN(s) who underwent ALND between 2005 and 2008 were selected from the Netherlands Cancer Registry. Logistic regression analysis was used to determine the association between ECE and 4 lymph node metastases. Five-year DFS and 10-year OS were analyzed using Kaplan-Meier survival analysis. Cox regression analysis was performed to correct for other prognostic factors.ResultsA total of 3502 patients were included. Information on ECE was available for 2111 (60.3%) patients, consisting of 741 (35.1%) patients with and 1370 (64.9%) without ECE. The incidence of 4 lymph node metastases was 116 (15.7%) in the ECE group vs. 80 (5.8%) in the group without ECE (p

KW - Breast cancer

KW - Sentinel lymph node

KW - Axillary lymph node dissection

KW - Extracapsular extension

KW - Disease-free survival

KW - Overall survival

KW - AXILLARY DISSECTION

KW - METASTASIS

KW - INVASION

KW - TRIAL

KW - PREDICTOR

KW - WOMEN

U2 - 10.1007/s10549-018-05074-y

DO - 10.1007/s10549-018-05074-y

M3 - Article

C2 - 30610488

SN - 0167-6806

VL - 174

SP - 711

EP - 718

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

IS - 3

ER -