TY - JOUR
T1 - External validation of an NTCP model for acute esophageal toxicity in locally advanced NSCLC patients treated with intensity-modulated (chemo-)radiotherapy
AU - Dankers, Frank J. W. M.
AU - Wijsman, Robin
AU - Troost, Esther G. C.
AU - Tissing-Tan, Caroline J. A.
AU - Kwint, Margriet H.
AU - Belderbos, Jose
AU - De Ruysscher, Dirk
AU - Hendriks, Lizza E.
AU - de Geus-Oei, Lioe-Fee
AU - Rodwell, Laura
AU - Dekker, Andre
AU - Monshouwer, Rene
AU - Hoffmann, Aswin L.
AU - Bussink, Johan
PY - 2018/11
Y1 - 2018/11
N2 - Background and purpose: We externally validated a previously established multivariable normal-tissue complication probability (NTCP) model for Grade >= 2 acute esophageal toxicity (AET) after intensity-modulated (chemo-)radiotherapy or volumetric-modulated arc therapy for locally advanced non-small cell lung cancer.Materials and methods: A total of 603 patients from five cohorts (A-E) within four different Dutch institutes were included. Using the NTCP model, containing predictors concurrent chemoradiotherapy, mean esophageal dose, gender and clinical tumor stage, the risk of Grade >= 2 AET was estimated per patient and model discrimination and (re) calibration performance were evaluated.Results: Four validation cohorts (A, B, D, E) experienced higher incidence of Grade >= 2 AET compared to the training cohort (49.3-70.2% vs 35.6%; borderline significant for one cohort, highly significant for three cohorts). Cohort C experienced lower Grade >= 2 AET incidence (21.7%, p <0.001). For three cohorts (A-C), discriminative performance was similar to the training cohort (area under the curve (AUC) 0.81-0.89 vs 0.84). In the two remaining cohorts (D-E) the model showed poor discriminative power (AUC 0.64 and 0.63). Reasonable calibration performance was observed in two cohorts (A-B), and recalibration further improved performance in all three cohorts with good discrimination (A-C). Recalibration for the two poorly discriminating cohorts (D-E) did not improve performance.Conclusions: The NTCP model for AET prediction was successfully validated in three out of five patient cohorts (AUC >= 0.80). The model did not perform well in two cohorts, which included patients receiving substantially different treatment. Before applying the model in clinical practice, validation of discrimination and (re) calibration performance in a local cohort is recommended. (C) 2018 Elsevier B.V. All rights reserved.
AB - Background and purpose: We externally validated a previously established multivariable normal-tissue complication probability (NTCP) model for Grade >= 2 acute esophageal toxicity (AET) after intensity-modulated (chemo-)radiotherapy or volumetric-modulated arc therapy for locally advanced non-small cell lung cancer.Materials and methods: A total of 603 patients from five cohorts (A-E) within four different Dutch institutes were included. Using the NTCP model, containing predictors concurrent chemoradiotherapy, mean esophageal dose, gender and clinical tumor stage, the risk of Grade >= 2 AET was estimated per patient and model discrimination and (re) calibration performance were evaluated.Results: Four validation cohorts (A, B, D, E) experienced higher incidence of Grade >= 2 AET compared to the training cohort (49.3-70.2% vs 35.6%; borderline significant for one cohort, highly significant for three cohorts). Cohort C experienced lower Grade >= 2 AET incidence (21.7%, p <0.001). For three cohorts (A-C), discriminative performance was similar to the training cohort (area under the curve (AUC) 0.81-0.89 vs 0.84). In the two remaining cohorts (D-E) the model showed poor discriminative power (AUC 0.64 and 0.63). Reasonable calibration performance was observed in two cohorts (A-B), and recalibration further improved performance in all three cohorts with good discrimination (A-C). Recalibration for the two poorly discriminating cohorts (D-E) did not improve performance.Conclusions: The NTCP model for AET prediction was successfully validated in three out of five patient cohorts (AUC >= 0.80). The model did not perform well in two cohorts, which included patients receiving substantially different treatment. Before applying the model in clinical practice, validation of discrimination and (re) calibration performance in a local cohort is recommended. (C) 2018 Elsevier B.V. All rights reserved.
KW - Non-small cell lung cancer
KW - Acute esophagitis
KW - Intensity-modulated radiation therapy
KW - Predictive modeling
KW - External validation
KW - CELL LUNG-CANCER
KW - 3-DIMENSIONAL CONFORMAL RADIOTHERAPY
KW - LOGISTIC-REGRESSION MODELS
KW - RADIATION-THERAPY
KW - PREDICTION MODELS
KW - DOSE PRESCRIPTION
KW - RTOG
KW - IMRT
KW - RISK
KW - PERFORMANCE
U2 - 10.1016/j.radonc.2018.07.021
DO - 10.1016/j.radonc.2018.07.021
M3 - Article
C2 - 30241789
SN - 0167-8140
VL - 129
SP - 249
EP - 256
JO - Radiotherapy and Oncology
JF - Radiotherapy and Oncology
IS - 2
ER -