Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Irene Fleur Kramer; Tim Snijders; Joey S. J. Smeets; Marika Leenders; Janneau van Kranenburg; Marcel den Hoed; Lex B. Verdijk; Martijn Poeze; Luc J. C. van Loon

doi:10.1093/gerona/glw253

Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Irene Fleur Kramer^*, Tim Snijders, Joey S. J. Smeets, Marika Leenders, Janneau van Kranenburg, Marcel den Hoed, Lex B. Verdijk, Martijn Poeze, Luc J. C. van Loon

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip fracture patients.

Method: Percutaneous needle biopsies were collected from the vastus lateralis muscle in 15 healthy young women (20 +/- 0.4 years), 15 healthy elderly women (79 +/- 1.7 years), and 15 elderly women with a fall-related hip fracture (82 +/- 1.5 years). Immunohistochemical analyses were performed to assess Type I and Type II muscle fiber size, and myonuclear and satellite cell content.

Results: Type II muscle fiber size was significantly different between all groups (p

Conclusion: Elderly female hip fracture patients show extensive Type II muscle fiber atrophy when compared with healthy young or agematched healthy elderly controls. Type II muscle fiber atrophy is an important hallmark of sarcopenia and may predispose to falls and (hip) fractures in the older population.

Original language	English
Pages (from-to)	1369-1375
Number of pages	7
Journal	Journals of Gerontology Series A-Biological Sciences and Medical Sciences
Volume	72
Issue number	10
DOIs	https://doi.org/10.1093/gerona/glw253
Publication status	Published - Oct 2017

Keywords

Falls
Hip fracture
Muscle
Sarcopenia
SATELLITE CELL CONTENT
DWELLING OLDER-PEOPLE
HUMAN SKELETAL-MUSCLE
RISK-FACTORS
TRAPEZIUS MUSCLE
FALLS
COMMUNITY
SARCOPENIA
STRENGTH
EXERCISE

Access to Document

10.1093/gerona/glw253

Cite this

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title = "Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients",

abstract = "Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip fracture patients.Method: Percutaneous needle biopsies were collected from the vastus lateralis muscle in 15 healthy young women (20 +/- 0.4 years), 15 healthy elderly women (79 +/- 1.7 years), and 15 elderly women with a fall-related hip fracture (82 +/- 1.5 years). Immunohistochemical analyses were performed to assess Type I and Type II muscle fiber size, and myonuclear and satellite cell content.Results: Type II muscle fiber size was significantly different between all groups (pConclusion: Elderly female hip fracture patients show extensive Type II muscle fiber atrophy when compared with healthy young or agematched healthy elderly controls. Type II muscle fiber atrophy is an important hallmark of sarcopenia and may predispose to falls and (hip) fractures in the older population.",

keywords = "Falls, Hip fracture, Muscle, Sarcopenia, SATELLITE CELL CONTENT, DWELLING OLDER-PEOPLE, HUMAN SKELETAL-MUSCLE, RISK-FACTORS, TRAPEZIUS MUSCLE, FALLS, COMMUNITY, SARCOPENIA, STRENGTH, EXERCISE",

author = "Kramer, {Irene Fleur} and Tim Snijders and Smeets, {Joey S. J.} and Marika Leenders and {van Kranenburg}, Janneau and {den Hoed}, Marcel and Verdijk, {Lex B.} and Martijn Poeze and {van Loon}, {Luc J. C.}",

year = "2017",

month = oct,

doi = "10.1093/gerona/glw253",

language = "English",

volume = "72",

pages = "1369--1375",

journal = "Journals of Gerontology Series A-Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "10",

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TY - JOUR

T1 - Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

AU - Kramer, Irene Fleur

AU - Snijders, Tim

AU - Smeets, Joey S. J.

AU - Leenders, Marika

AU - van Kranenburg, Janneau

AU - den Hoed, Marcel

AU - Verdijk, Lex B.

AU - Poeze, Martijn

AU - van Loon, Luc J. C.

PY - 2017/10

Y1 - 2017/10

N2 - Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip fracture patients.Method: Percutaneous needle biopsies were collected from the vastus lateralis muscle in 15 healthy young women (20 +/- 0.4 years), 15 healthy elderly women (79 +/- 1.7 years), and 15 elderly women with a fall-related hip fracture (82 +/- 1.5 years). Immunohistochemical analyses were performed to assess Type I and Type II muscle fiber size, and myonuclear and satellite cell content.Results: Type II muscle fiber size was significantly different between all groups (pConclusion: Elderly female hip fracture patients show extensive Type II muscle fiber atrophy when compared with healthy young or agematched healthy elderly controls. Type II muscle fiber atrophy is an important hallmark of sarcopenia and may predispose to falls and (hip) fractures in the older population.

AB - Background: Sarcopenia, or the loss of muscle mass and strength, is known to increase the risk for falls and (hip) fractures in older people. The objective of this study was to assess the skeletal muscle fiber characteristics in elderly female hip fracture patients.Method: Percutaneous needle biopsies were collected from the vastus lateralis muscle in 15 healthy young women (20 +/- 0.4 years), 15 healthy elderly women (79 +/- 1.7 years), and 15 elderly women with a fall-related hip fracture (82 +/- 1.5 years). Immunohistochemical analyses were performed to assess Type I and Type II muscle fiber size, and myonuclear and satellite cell content.Results: Type II muscle fiber size was significantly different between all groups (pConclusion: Elderly female hip fracture patients show extensive Type II muscle fiber atrophy when compared with healthy young or agematched healthy elderly controls. Type II muscle fiber atrophy is an important hallmark of sarcopenia and may predispose to falls and (hip) fractures in the older population.

KW - Falls

KW - Hip fracture

KW - Muscle

KW - Sarcopenia

KW - SATELLITE CELL CONTENT

KW - DWELLING OLDER-PEOPLE

KW - HUMAN SKELETAL-MUSCLE

KW - RISK-FACTORS

KW - TRAPEZIUS MUSCLE

KW - FALLS

KW - COMMUNITY

KW - SARCOPENIA

KW - STRENGTH

KW - EXERCISE

U2 - 10.1093/gerona/glw253

DO - 10.1093/gerona/glw253

M3 - Article

C2 - 28329045

SN - 1079-5006

VL - 72

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EP - 1375

JO - Journals of Gerontology Series A-Biological Sciences and Medical Sciences

JF - Journals of Gerontology Series A-Biological Sciences and Medical Sciences

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