Abstract
Cardiac resynchronization therapy (CRT) is an important therapy for heart failure patients with prolonged QRS duration. In patients with left bundle branch block the altered left ventricular electrical activation results in dyssynchronous, inefficient contraction of the left ventricle. CRT aims to reverse these changes and to improve cardiac function. This article explores the electrophysiologic and hemodynamic changes that occur during CRT in patient and animal studies. It also addresses how novel techniques, such as multipoint and endocardial pacing, can further improve the electromechanical response.
Original language | English |
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Pages (from-to) | 599-608 |
Number of pages | 10 |
Journal | Cardiac Electrophysiology Clinics |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2015 |
Keywords
- Animals
- Bundle-Branch Block
- Cardiac Resynchronization Therapy
- Excitation Contraction Coupling
- Heart Conduction System
- Heart Failure
- Models, Cardiovascular
- Myocardial Contraction
- Translational Medical Research
- Treatment Outcome
- Ventricular Dysfunction, Left