Evaluation of in vitro immunotoxicity tests using transcriptomics

P.C.J. Schmeits

doi:10.26481/dis.20151113ps

Evaluation of in vitro immunotoxicity tests using transcriptomics

P.C.J. Schmeits

Research output: Thesis › Doctoral Thesis › Internal

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Abstract

Peter Schmeits researched the detection of substances that are toxic to immune cells by culturing different cell lines in plastic containers and exposing them to toxic and non-toxic substances for immune cells. He then measured the effects on the activation of all genes (roughly 22,000 messenger RNAs). This generated new insights into the substances' modes of action. Previous research has identified a group of twenty-five marker genes that can predict the toxicity of a substance for the immune system, which was confirmed in a new experiment using different substances. This alternative method may one day be replicated using animal studies.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Maastricht University
Supervisors/Advisors	van Loveren, Henk, Supervisor Peijnenburg, A., Co-Supervisor, External person
Award date	13 Nov 2015
Place of Publication	's-Hertogenbosch
Publisher	Uitgeverij BOXPress
Print ISBNs	9789462952775
DOIs	https://doi.org/10.26481/dis.20151113ps
Publication status	Published - 2015

Keywords

toxic substances
immune cells
in vitro

Access to Document

10.26481/dis.20151113ps

Full TextFinal published version, 5.93 MB
AbstractFinal published version, 228 KB
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CoverFinal published version, 224 KB
ValorisationFinal published version, 225 KB

Cite this

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