European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt; Colin D. Veal; Lea ter Meulen; Charalambos Chrysostomou; Wiesje van der Flier; Giovanni B. Frisoni; Idris Guessous; Miia Kivipelto; Moira Marizzoni; Pablo Martinez-Lage; Jose Molinuevo; David Porteous; Karen Ritchie; Philip Scheltens; Pierre-Jean Ousset; Craig W. Ritchie; Gerald Luscan; Anthony J. Brookes; Pieter Jelle Visser

doi:10.1016/j.jalz.2018.02.010

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt^*, Colin D. Veal, Lea ter Meulen, Charalambos Chrysostomou, Wiesje van der Flier, Giovanni B. Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-Lage, Jose Molinuevo, David Porteous, Karen Ritchie, Philip Scheltens, Pierre-Jean Ousset, Craig W. Ritchie, Gerald Luscan, Anthony J. Brookes, Pieter Jelle Visser

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	837-842
Number of pages	6
Journal	Alzheimer's & Dementia
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2018.02.010
Publication status	Published - 1 Jun 2018

Keywords

Preclinical AD
Prodromal AD
Clinical trial
Participant recruitment
Research registry
EPAD

Access to Document

10.1016/j.jalz.2018.02.010Licence: Unspecified

Cite this

Vermunt, L., Veal, C. D., ter Meulen, L., Chrysostomou, C., van der Flier, W., Frisoni, G. B., Guessous, I., Kivipelto, M., Marizzoni, M., Martinez-Lage, P., Molinuevo, J., Porteous, D., Ritchie, K., Scheltens, P., Ousset, P.-J., Ritchie, C. W., Luscan, G., Brookes, A. J., & Visser, P. J. (2018). European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials. Alzheimer's & Dementia, 14(6), 837-842. https://doi.org/10.1016/j.jalz.2018.02.010

@article{c87976e0d5df46369ac9f3f231d92381,

title = "European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials",

abstract = "Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.",

keywords = "Preclinical AD, Prodromal AD, Clinical trial, Participant recruitment, Research registry, EPAD",

author = "Lisa Vermunt and Veal, {Colin D.} and {ter Meulen}, Lea and Charalambos Chrysostomou and {van der Flier}, Wiesje and Frisoni, {Giovanni B.} and Idris Guessous and Miia Kivipelto and Moira Marizzoni and Pablo Martinez-Lage and Jose Molinuevo and David Porteous and Karen Ritchie and Philip Scheltens and Pierre-Jean Ousset and Ritchie, {Craig W.} and Gerald Luscan and Brookes, {Anthony J.} and Visser, {Pieter Jelle}",

year = "2018",

month = jun,

day = "1",

doi = "10.1016/j.jalz.2018.02.010",

language = "English",

volume = "14",

pages = "837--842",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier Science",

number = "6",

}

Vermunt, L, Veal, CD, ter Meulen, L, Chrysostomou, C, van der Flier, W, Frisoni, GB, Guessous, I, Kivipelto, M, Marizzoni, M, Martinez-Lage, P, Molinuevo, J, Porteous, D, Ritchie, K, Scheltens, P, Ousset, P-J, Ritchie, CW, Luscan, G, Brookes, AJ & Visser, PJ 2018, 'European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials', Alzheimer's & Dementia, vol. 14, no. 6, pp. 837-842. https://doi.org/10.1016/j.jalz.2018.02.010

TY - JOUR

T1 - European Prevention of Alzheimer's Dementia Registry

T2 - Recruitment and prescreening approach for a longitudinal cohort and prevention trials

AU - Vermunt, Lisa

AU - Veal, Colin D.

AU - ter Meulen, Lea

AU - Chrysostomou, Charalambos

AU - van der Flier, Wiesje

AU - Frisoni, Giovanni B.

AU - Guessous, Idris

AU - Kivipelto, Miia

AU - Marizzoni, Moira

AU - Martinez-Lage, Pablo

AU - Molinuevo, Jose

AU - Porteous, David

AU - Ritchie, Karen

AU - Scheltens, Philip

AU - Ousset, Pierre-Jean

AU - Ritchie, Craig W.

AU - Luscan, Gerald

AU - Brookes, Anthony J.

AU - Visser, Pieter Jelle

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

AB - Introduction: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach. Methods: Avirtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up. Results: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort. Discussion: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

KW - Preclinical AD

KW - Prodromal AD

KW - Clinical trial

KW - Participant recruitment

KW - Research registry

KW - EPAD

U2 - 10.1016/j.jalz.2018.02.010

DO - 10.1016/j.jalz.2018.02.010

M3 - Article

SN - 1552-5260

VL - 14

SP - 837

EP - 842

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

IS - 6

ER -