Abstract
Recent studies have suggested a role for epigenetic mechanisms in the complex etiology of various neurode-generative diseases. In this review, we discuss advances that have been made toward understanding the role of epigenetic processes in neurodegenerative disorders, with a particular focus on Alzheimer's disease, where the most extensive studies have been undertaken to date. We provide a brief overview of DNA modifications, followed by a summarization of studies of DNA modifications in Alzheimer's disease and other neurodegenerative diseases.
Original language | English |
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Pages (from-to) | 158-170 |
Number of pages | 13 |
Journal | Journal of Neurochemistry |
Volume | 143 |
Issue number | 2 |
DOIs | |
Publication status | Published - Oct 2017 |
Keywords
- Alzheimer's disease
- DNA hydroxymethylation
- DNA methylation
- epigenetic
- epigenome-wide association study
- genetic
- MESSENGER-RNA EXPRESSION
- AMYOTROPHIC-LATERAL-SCLEROSIS
- PROMOTER METHYLATION LEVELS
- SUPERIOR TEMPORAL GYRUS
- PRECURSOR PROTEIN GENE
- ALPHA-SYNUCLEIN GENE
- HUMAN BASAL GANGLIA
- PARKINSONS-DISEASE
- LEUKOCYTE DNA
- MAMMALIAN DNA