Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke

Joseph P. Broderick; Olvert A. Berkhemer; Yuko Y. Palesch; Diederik W. J. Dippel; Lydia D. Foster; Yvo B. W. E. M. Roos; Aad van der Lugt; Thomas A. Tomsick; Charles B. L. M. Majoie; Wim H. van Zwam; Andrew M. Demchuk; Robert J. van Oostenbrugge; Pooja Khatri; Hester F. Lingsma; Michael D. Hill; Bob Roozenbeek; Edward C. Jauch; Tudor G. Jovin; Bernard Yan; Ruediger von Kummer; Carlos A. Molina; Mayank Goyal; Wouter J. Schonewille; Mikael Mazighi; Stefan T. Engelter; Craig S. Anderson; Judith Spilker; Janice Carrozzella; Karla J. Ryckborst; L. Scott Janis; Kit N. Simpson

doi:10.1161/STROKEAHA.115.011397

Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke

Joseph P. Broderick^*, Olvert A. Berkhemer, Yuko Y. Palesch, Diederik W. J. Dippel, Lydia D. Foster, Yvo B. W. E. M. Roos, Aad van der Lugt, Thomas A. Tomsick, Charles B. L. M. Majoie, Wim H. van Zwam, Andrew M. Demchuk, Robert J. van Oostenbrugge, Pooja Khatri, Hester F. Lingsma, Michael D. Hill, Bob Roozenbeek, Edward C. Jauch, Tudor G. Jovin, Bernard Yan, Ruediger von KummerCarlos A. Molina, Mayank Goyal, Wouter J. Schonewille, Mikael Mazighi, Stefan T. Engelter, Craig S. Anderson, Judith Spilker, Janice Carrozzella, Karla J. Ryckborst, L. Scott Janis, Kit N. Simpson

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and Purpose-We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, >= 20) after a prespecified analysis plan. Methods-The pooled analysis of the Interventional Management of Stroke III (IMS III) and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trials included participants with an National Institutes of Health Stroke Scale score of >= 20 before intravenous tissue-type plasminogen activator (tPA) treatment (IMS III) or randomization (MR CLEAN) who were treated with intravenous tPA

Original language	English
Pages (from-to)	3416-3422
Journal	Stroke
Volume	46
Issue number	12
DOIs	https://doi.org/10.1161/STROKEAHA.115.011397
Publication status	Published - Dec 2015

Keywords

clinical trial
endovascular procedures
stroke
tissue-type plasminogen activator

Access to Document

10.1161/STROKEAHA.115.011397

Cite this

Broderick, J. P., Berkhemer, O. A., Palesch, Y. Y., Dippel, D. W. J., Foster, L. D., Roos, Y. B. W. E. M., van der Lugt, A., Tomsick, T. A., Majoie, C. B. L. M., van Zwam, W. H., Demchuk, A. M., van Oostenbrugge, R. J., Khatri, P., Lingsma, H. F., Hill, M. D., Roozenbeek, B., Jauch, E. C., Jovin, T. G., Yan, B., ... Simpson, K. N. (2015). Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke. Stroke, 46(12), 3416-3422. https://doi.org/10.1161/STROKEAHA.115.011397

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title = "Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke",

abstract = "Background and Purpose-We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, >= 20) after a prespecified analysis plan. Methods-The pooled analysis of the Interventional Management of Stroke III (IMS III) and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trials included participants with an National Institutes of Health Stroke Scale score of >= 20 before intravenous tissue-type plasminogen activator (tPA) treatment (IMS III) or randomization (MR CLEAN) who were treated with intravenous tPA ",

keywords = "clinical trial, endovascular procedures, stroke, tissue-type plasminogen activator",

author = "Broderick, {Joseph P.} and Berkhemer, {Olvert A.} and Palesch, {Yuko Y.} and Dippel, {Diederik W. J.} and Foster, {Lydia D.} and Roos, {Yvo B. W. E. M.} and {van der Lugt}, Aad and Tomsick, {Thomas A.} and Majoie, {Charles B. L. M.} and {van Zwam}, {Wim H.} and Demchuk, {Andrew M.} and {van Oostenbrugge}, {Robert J.} and Pooja Khatri and Lingsma, {Hester F.} and Hill, {Michael D.} and Bob Roozenbeek and Jauch, {Edward C.} and Jovin, {Tudor G.} and Bernard Yan and {von Kummer}, Ruediger and Molina, {Carlos A.} and Mayank Goyal and Schonewille, {Wouter J.} and Mikael Mazighi and Engelter, {Stefan T.} and Anderson, {Craig S.} and Judith Spilker and Janice Carrozzella and Ryckborst, {Karla J.} and Janis, {L. Scott} and Simpson, {Kit N.}",

year = "2015",

month = dec,

doi = "10.1161/STROKEAHA.115.011397",

language = "English",

volume = "46",

pages = "3416--3422",

journal = "Stroke",

issn = "0039-2499",

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Broderick, JP, Berkhemer, OA, Palesch, YY, Dippel, DWJ, Foster, LD, Roos, YBWEM, van der Lugt, A, Tomsick, TA, Majoie, CBLM, van Zwam, WH, Demchuk, AM, van Oostenbrugge, RJ, Khatri, P, Lingsma, HF, Hill, MD, Roozenbeek, B, Jauch, EC, Jovin, TG, Yan, B, von Kummer, R, Molina, CA, Goyal, M, Schonewille, WJ, Mazighi, M, Engelter, ST, Anderson, CS, Spilker, J, Carrozzella, J, Ryckborst, KJ, Janis, LS & Simpson, KN 2015, 'Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke', Stroke, vol. 46, no. 12, pp. 3416-3422. https://doi.org/10.1161/STROKEAHA.115.011397

TY - JOUR

T1 - Endovascular Therapy Is Effective and Safe for Patients With Severe Ischemic Stroke

AU - Broderick, Joseph P.

AU - Berkhemer, Olvert A.

AU - Palesch, Yuko Y.

AU - Dippel, Diederik W. J.

AU - Foster, Lydia D.

AU - Roos, Yvo B. W. E. M.

AU - van der Lugt, Aad

AU - Tomsick, Thomas A.

AU - Majoie, Charles B. L. M.

AU - van Zwam, Wim H.

AU - Demchuk, Andrew M.

AU - van Oostenbrugge, Robert J.

AU - Khatri, Pooja

AU - Lingsma, Hester F.

AU - Hill, Michael D.

AU - Roozenbeek, Bob

AU - Jauch, Edward C.

AU - Jovin, Tudor G.

AU - Yan, Bernard

AU - von Kummer, Ruediger

AU - Molina, Carlos A.

AU - Goyal, Mayank

AU - Schonewille, Wouter J.

AU - Mazighi, Mikael

AU - Engelter, Stefan T.

AU - Anderson, Craig S.

AU - Spilker, Judith

AU - Carrozzella, Janice

AU - Ryckborst, Karla J.

AU - Janis, L. Scott

AU - Simpson, Kit N.

PY - 2015/12

Y1 - 2015/12

N2 - Background and Purpose-We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, >= 20) after a prespecified analysis plan. Methods-The pooled analysis of the Interventional Management of Stroke III (IMS III) and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trials included participants with an National Institutes of Health Stroke Scale score of >= 20 before intravenous tissue-type plasminogen activator (tPA) treatment (IMS III) or randomization (MR CLEAN) who were treated with intravenous tPA

AB - Background and Purpose-We assessed the effect of endovascular treatment in acute ischemic stroke patients with severe neurological deficit (National Institutes of Health Stroke Scale score, >= 20) after a prespecified analysis plan. Methods-The pooled analysis of the Interventional Management of Stroke III (IMS III) and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) trials included participants with an National Institutes of Health Stroke Scale score of >= 20 before intravenous tissue-type plasminogen activator (tPA) treatment (IMS III) or randomization (MR CLEAN) who were treated with intravenous tPA

KW - clinical trial

KW - endovascular procedures

KW - stroke

KW - tissue-type plasminogen activator

U2 - 10.1161/STROKEAHA.115.011397

DO - 10.1161/STROKEAHA.115.011397

M3 - Article

C2 - 26486865

SN - 0039-2499

VL - 46

SP - 3416

EP - 3422

JO - Stroke

JF - Stroke

IS - 12

ER -