Abstract
The objective of this study was to investigate the efficacy of lipid emulsions encapsulated in calcium-alginate beads in reducing food intake and appetite sensations. These emulsion-alginate beads were ingested in a yogurt (active) and compared to an equienergetic yogurt containing nonencapsulated nutrients with comparable sensory properties (control) in a randomized placebo-controlled trial with crossover design. Thirty-three healthy overweight volunteers (mean age: 43 years; body mass index: 27.7 kg/m(2); 14 male) received the 2 treatments. Test days started with a standardized small breakfast (t = 0) followed by an active or control yogurt (t = 90 minutes). Appetite sensations and gastrointestinal symptoms were monitored prior to and after consumption of the yogurt, and food intake was measured during ad libitum pasta meal consumption (t = 210 minutes). The hypothesis for this study was that delayed release of encapsulated lipids suppresses appetite sensations and reduces food intake. Food intake was significantly reduced with 51 +/- 20 kcal (213 +/- 84 kJ) (P =.016) after intake of the active yogurt (770 +/- 38 kcal (3222 +/- 159 kJ)) compared to the control (821 +/- 40 kcal (3435 +/- 167 kJ)). The approach that we chose is promising to reduce food intake and could contribute to the development of an easy-to-use product for weight management. (C) 2018 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 86-94 |
Number of pages | 9 |
Journal | Nutrition Research |
Volume | 63 |
DOIs | |
Publication status | Published - Mar 2019 |
Keywords
- Appetite
- Human trial
- Ileal brake
- Weight management
- Encapsulated lipid
- FREE FATTY-ACIDS
- DROPLET SIZE
- ILEAL BRAKE
- APPETITE
- SATIETY
- LIPOLYSIS
- DIGESTION
- IMPACT
- INTERFACES
- BEHAVIOR