Elevated HbA(1c) and Fasting Plasma Glucose in Predicting Diabetes Incidence Among Older Adults Are two better than one?

Kasia J. Lipska; Silvio E. Inzucchi; Peter H. Van Ness; Thomas M. Gill; Alka Kanaya; Elsa S. Strotmeyer; Annemarie Koster; Karen C. Johnson; Bret H. Goodpaster; Tamara Harris; Nathalie De Rekeneire

doi:10.2337/dc12-2631

Elevated HbA(1c) and Fasting Plasma Glucose in Predicting Diabetes Incidence Among Older Adults Are two better than one?

Kasia J. Lipska^*, Silvio E. Inzucchi, Peter H. Van Ness, Thomas M. Gill, Alka Kanaya, Elsa S. Strotmeyer, Annemarie Koster, Karen C. Johnson, Bret H. Goodpaster, Tamara Harris, Nathalie De Rekeneire

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE To determine which measuresimpaired fasting glucose (IFG), elevated HbA(1c), or bothbest predict incident diabetes in older adults.RESEARCH DESIGN AND METHODSFrom the Health, Aging, and Body Composition study, we selected individuals without diabetes, and we defined IFG (100-125 mg/dL) and elevated HbA(1c) (5.7-6.4%) per American Diabetes Association guidelines. Incident diabetes was based on self-report, use of antihyperglycemic medicines, or HbA(1c) 6.5% during 7 years of follow-up. Logistic regression analyses were adjusted for age, sex, race, site, BMI, smoking, blood pressure, and physical activity. Discrimination and calibration were assessed for models with IFG and with both IFG and elevated HbA(1c).RESULTSAmong 1,690 adults (mean age 76.5, 46% men, 32% black), 183 (10.8%) developed diabetes over 7 years. Adjusted odds ratios of diabetes were 6.2 (95% CI 4.4-8.8) in those with IFG (versus those with fasting plasma glucose [FPG]

Original language	English
Pages (from-to)	3923-3929
Journal	Diabetes Care
Volume	36
Issue number	12
DOIs	https://doi.org/10.2337/dc12-2631
Publication status	Published - Dec 2013

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10.2337/dc12-2631Licence: CC BY-NC-ND

Cite this

@article{fab9eee26bcc430c9efb73f7ecc4804a,

title = "Elevated HbA(1c) and Fasting Plasma Glucose in Predicting Diabetes Incidence Among Older Adults Are two better than one?",

abstract = "OBJECTIVE To determine which measuresimpaired fasting glucose (IFG), elevated HbA(1c), or bothbest predict incident diabetes in older adults.RESEARCH DESIGN AND METHODSFrom the Health, Aging, and Body Composition study, we selected individuals without diabetes, and we defined IFG (100-125 mg/dL) and elevated HbA(1c) (5.7-6.4%) per American Diabetes Association guidelines. Incident diabetes was based on self-report, use of antihyperglycemic medicines, or HbA(1c) 6.5% during 7 years of follow-up. Logistic regression analyses were adjusted for age, sex, race, site, BMI, smoking, blood pressure, and physical activity. Discrimination and calibration were assessed for models with IFG and with both IFG and elevated HbA(1c).RESULTSAmong 1,690 adults (mean age 76.5, 46% men, 32% black), 183 (10.8%) developed diabetes over 7 years. Adjusted odds ratios of diabetes were 6.2 (95% CI 4.4-8.8) in those with IFG (versus those with fasting plasma glucose [FPG] ",

author = "Lipska, {Kasia J.} and Inzucchi, {Silvio E.} and {Van Ness}, {Peter H.} and Gill, {Thomas M.} and Alka Kanaya and Strotmeyer, {Elsa S.} and Annemarie Koster and Johnson, {Karen C.} and Goodpaster, {Bret H.} and Tamara Harris and {De Rekeneire}, Nathalie",

year = "2013",

month = dec,

doi = "10.2337/dc12-2631",

language = "English",

volume = "36",

pages = "3923--3929",

journal = "Diabetes Care",

issn = "0149-5992",