Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns

Andrea Sannia; Luc J. I. Zimmermann; Antonio W. D. Gavilanes; Hans J. Vles; Maria Grazia Calevo; Pasquale Florio; Diego Gazzolo

doi:10.1111/apa.12332

Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns

Andrea Sannia, Luc J. I. Zimmermann, Antonio W. D. Gavilanes, Hans J. Vles, Maria Grazia Calevo, Pasquale Florio, Diego Gazzolo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72h and at 1week after birth, respectively. Results Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p

Original language	English
Pages (from-to)	E449-E454
Journal	Acta Paediatrica
Volume	102
Issue number	10
DOIs	https://doi.org/10.1111/apa.12332
Publication status	Published - Oct 2013

Keywords

Activin A
Biomarkers
Brain damage
IVH
Prematurity

Access to Document

10.1111/apa.12332

Cite this

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title = "Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns",

abstract = "Aim Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72h and at 1week after birth, respectively. Results Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p",

keywords = "Activin A, Biomarkers, Brain damage, IVH, Prematurity",

author = "Andrea Sannia and Zimmermann, {Luc J. I.} and Gavilanes, {Antonio W. D.} and Vles, {Hans J.} and Calevo, {Maria Grazia} and Pasquale Florio and Diego Gazzolo",

year = "2013",

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T1 - Elevated Activin A urine levels are predictors of intraventricular haemorrhage in preterm newborns

AU - Sannia, Andrea

AU - Zimmermann, Luc J. I.

AU - Gavilanes, Antonio W. D.

AU - Vles, Hans J.

AU - Calevo, Maria Grazia

AU - Florio, Pasquale

AU - Gazzolo, Diego

PY - 2013/10

Y1 - 2013/10

N2 - Aim Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72h and at 1week after birth, respectively. Results Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p

AB - Aim Intraventricular haemorrhage (IVH) is the most common variety of cerebral haemorrhage and cause of neurological disabilities in preterm newborns. We evaluated the usefulness of urine Activin A concentrations for the early detection of perinatal IVH. Methods We conducted a case-control study on 100 preterm newborns (20 with IVH and 80 without IVH) in whom urine Activin A was measured at five predetermined time-points in the first 72h after birth. IVH diagnosis and the extension of the lesion were performed by ultrasound scanning within the first 72h and at 1week after birth, respectively. Results Urine Activin A in infants who developed IVH was significantly higher than in controls at all monitoring time-points (p

KW - Activin A

KW - Biomarkers

KW - Brain damage

KW - IVH

KW - Prematurity

U2 - 10.1111/apa.12332

DO - 10.1111/apa.12332

M3 - Article

C2 - 23808611

SN - 0803-5253

VL - 102

SP - E449-E454

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 10

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