Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?

G.J.M. den Hartog; G.R.M.M. Haenen; E. Vegt; W.J.F. van der Vijgh; A. Bast

doi:10.1515/BC.2002.073

Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?

G.J.M. den Hartog^*, G.R.M.M. Haenen, E. Vegt, W.J.F. van der Vijgh, A. Bast

^*Corresponding author for this work

NUTRIM School of Nutrition and Translational Research in Metabolism

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Hypochlorous acid (HOCl) is a bactericidal compound formed by activated neutrophils during inflammation. Overproduction of HOCl causes damage to tissues at the site of neutrophil accumulation. The deleterious effects of excessive HOCl formation can be attenuated using antioxidants. Thiols and thioethers are known to be very effective HOCl scavengers. In the present study, the potency of several sulfurcontaining compounds to protect acetylcholinesterase, glutathione Stransferase P1-1 (GST P1-1) and α1-antiproteinease against inactivation by HOCl was determined. Surprisingly, glutathione disulfide was an effective protector of acetylcholinesterase against hypochlorous acid. Glutathione disulfide did not provide protection for GST P1-1 and α1-antiproteinease against oxidative inactivation by HOCl. The implications of this finding are discussed.

Original language	English
Pages (from-to)	709-713
Number of pages	5
Journal	Biological Chemistry
Volume	383
Issue number	3-4
DOIs	https://doi.org/10.1515/BC.2002.073
Publication status	Published - 1 Jan 2002

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10.1515/BC.2002.073

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title = "Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide?",

abstract = "Hypochlorous acid (HOCl) is a bactericidal compound formed by activated neutrophils during inflammation. Overproduction of HOCl causes damage to tissues at the site of neutrophil accumulation. The deleterious effects of excessive HOCl formation can be attenuated using antioxidants. Thiols and thioethers are known to be very effective HOCl scavengers. In the present study, the potency of several sulfurcontaining compounds to protect acetylcholinesterase, glutathione Stransferase P1-1 (GST P1-1) and α1-antiproteinease against inactivation by HOCl was determined. Surprisingly, glutathione disulfide was an effective protector of acetylcholinesterase against hypochlorous acid. Glutathione disulfide did not provide protection for GST P1-1 and α1-antiproteinease against oxidative inactivation by HOCl. The implications of this finding are discussed.",

author = "{den Hartog}, G.J.M. and G.R.M.M. Haenen and E. Vegt and {van der Vijgh}, W.J.F. and A. Bast",

year = "2002",

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doi = "10.1515/BC.2002.073",

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TY - JOUR

T1 - Efficacy of HOCl scavenging by sulfur-containing compounds

T2 - antioxidant activity of glutathione disulfide?

AU - den Hartog, G.J.M.

AU - Haenen, G.R.M.M.

AU - Vegt, E.

AU - van der Vijgh, W.J.F.

AU - Bast, A.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Hypochlorous acid (HOCl) is a bactericidal compound formed by activated neutrophils during inflammation. Overproduction of HOCl causes damage to tissues at the site of neutrophil accumulation. The deleterious effects of excessive HOCl formation can be attenuated using antioxidants. Thiols and thioethers are known to be very effective HOCl scavengers. In the present study, the potency of several sulfurcontaining compounds to protect acetylcholinesterase, glutathione Stransferase P1-1 (GST P1-1) and α1-antiproteinease against inactivation by HOCl was determined. Surprisingly, glutathione disulfide was an effective protector of acetylcholinesterase against hypochlorous acid. Glutathione disulfide did not provide protection for GST P1-1 and α1-antiproteinease against oxidative inactivation by HOCl. The implications of this finding are discussed.

AB - Hypochlorous acid (HOCl) is a bactericidal compound formed by activated neutrophils during inflammation. Overproduction of HOCl causes damage to tissues at the site of neutrophil accumulation. The deleterious effects of excessive HOCl formation can be attenuated using antioxidants. Thiols and thioethers are known to be very effective HOCl scavengers. In the present study, the potency of several sulfurcontaining compounds to protect acetylcholinesterase, glutathione Stransferase P1-1 (GST P1-1) and α1-antiproteinease against inactivation by HOCl was determined. Surprisingly, glutathione disulfide was an effective protector of acetylcholinesterase against hypochlorous acid. Glutathione disulfide did not provide protection for GST P1-1 and α1-antiproteinease against oxidative inactivation by HOCl. The implications of this finding are discussed.

U2 - 10.1515/BC.2002.073

DO - 10.1515/BC.2002.073

M3 - Article

SN - 1431-6730

VL - 383

SP - 709

EP - 713

JO - Biological Chemistry

JF - Biological Chemistry

IS - 3-4

ER -