TY - JOUR
T1 - Effects of Urocortin 2 Versus Urocortin 3 Gene Transfer on Left Ventricular Function and Glucose Disposal
AU - Giamouridis, Dimosthenis
AU - Gao, Meihua
AU - Lai, Ngai Chin
AU - Tan, Zhen
AU - Kim, Byung Chul
AU - Guo, Tracy
AU - Miyanohara, Atsushi
AU - Blankesteijn, Matthijs
AU - Biessen, Erik
AU - Hammond, H. Kirk
PY - 2018
Y1 - 2018
N2 - UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plasma concentrations of the peptides. This was associated with increases in both systolic and diastolic left ventricular (LV) function, mediated by increased LV SERCA2a expression and Ca2þ handling. UCn2, but not UCn3, gene transfer reduced fasting glucose and increased glucose disposal. These findings support UCn2 and UCn3 gene transfer as potential treatments for HF and indicate that UCn2 may be an optimal selection in patients with diabetes and HF.
AB - UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plasma concentrations of the peptides. This was associated with increases in both systolic and diastolic left ventricular (LV) function, mediated by increased LV SERCA2a expression and Ca2þ handling. UCn2, but not UCn3, gene transfer reduced fasting glucose and increased glucose disposal. These findings support UCn2 and UCn3 gene transfer as potential treatments for HF and indicate that UCn2 may be an optimal selection in patients with diabetes and HF.
U2 - 10.1016/j.jacbts.2017.12.004
DO - 10.1016/j.jacbts.2017.12.004
M3 - Article
C2 - 30062211
SN - 2452-302X
VL - 3
SP - 249
EP - 264
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 2
ER -