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Effects of tyrosine/phenylalanine depletion on electrophysiological correlates of memory in healthy volunteers

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Abstract

Dopamine is well known for involvement in reinforcement, motor control and frontal lobe functions, such as attention and memory. Tyrosine/phenylalanine depletion (TPD) lowers dopamine synthesis and can therefore be used as a model to study the effects of low dopamine levels. This is the first study to assess the effect of TPD on memory performance and its electrophysiological correlates. In a double blind placebo (PLA)-controlled crossover design, 17 healthy volunteers (six males, 11 females) aged between 18 and 25 were tested after TPD and PLA. Working memory was assessed using a Sternberg memory scanning task (SMS) and episodic memory using the Visual Verbal Learning Test (VVLT). Simultaneously, event-related potentials (ERPs) were measured. The tyrosine and phenylalanine ratio was significantly reduced after TPD and increased after PLA. Working memory performance was not affected by TPD. However, ERP measures were affected by the treatment, indicating that TPD impaired stimulus processing during working memory performance. Episodic memory was not impaired after TPD. Again, alterations in ERP measures suggested adverse effects of TPD on memory-related processing. These results suggest that dopamine is involved in both working memory and episodic memory-related processing, although the effects are too small to be detected by performance measures.

    Research areas

  • dopamine, tyrosine and phenylalanine depletion, working memory, episodic memory, event-related potentials, SPATIAL WORKING-MEMORY, ACUTE PHENYLALANINE/TYROSINE DEPLETION, ACUTE TYROSINE DEPLETION, AMINO-ACID MIXTURE, PARKINSONS-DISEASE, TRYPTOPHAN DEPLETION, DOPAMINERGIC MODULATION, RESPONSE CONFLICT, MOOD, SEROTONIN
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Details

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalJournal of Psychopharmacology
Volume25
Issue number2
DOIs
Publication statusPublished - Feb 2011