@article{add1cb417ac1418ea60a314cd0bfb7f4,
title = "Effects of dietary fat on insulin secretion in subjects with the metabolic syndrome",
abstract = "Objective: Impaired insulin secretion and action contribute to the development of type 2 diabetes. Dietary fat modification may improve insulin sensitivity, whereas the effect on insulin secretion is unclear. We investigated the effect of dietary fat modification on insulin secretion in subjects with the metabolic syndrome.Design: In a 12-week pan-European parallel, randomized controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to four isoenergetic diets: high-fat diets rich in saturated fat (HSFA) or monounsaturated fat (HMUFA) or low-fat, high-complex carbohydrate diets with (LFHCC n-3) or without (LFHCC control) 1.2 g/day of n-3 PUFA supplementation. Insulin secretion was estimated as acute insulin response to glucose (AIRg) and disposition index (DI), modeled from an intravenous glucose tolerance test.Results: There were no overall effect of the dietary intervention on AIRg and DI in the total cohort, in neither the highfat nor LFHCC groups. We observed significant diet*fasting glucose category interactions for AIRg (P = 0.021) and DI (P = 0.001) in the high-fat groups. In subjects with normal fasting glucose and preserved first phase insulin secretion, the HMUFA diet increased, whereas the HSFA diet reduced AIRg (P = 0.015) and DI (P = 0.010).Conclusions: The effects of dietary fat modification on insulin secretion were minor, and only evident in normoglycemic subjects. In this case, the HMUFA diet improved AIRg and DI, as compared to the HSFA diet.",
keywords = "LIFE-STYLE INTERVENTION, BETA-CELL FUNCTION, GLUCOSE-TOLERANCE, DIABETES-MELLITUS, SENSITIVITY, ACIDS, PREVENTION, RESISTANCE, SUPPLEMENTATION, DYSFUNCTION",
author = "Gulseth, {Hanne L.} and Gjelstad, {Ingrid M. F.} and Tiereny, {Audrey C.} and Danielle McCarthy and Lovegrove, {Julie A.} and Catherine Defoort and Blaak, {Ellen E.} and Jose Lopez-Miranda and Aldona Dembinska-Kiec and Ulf Riserus and Roche, {Helen M.} and Drevon, {Christian A.} and Kare Birkeland",
note = "Funding Information: The study has been supported by LIPGENE – an EU 6th Framework Program Integrated Project (FOOD-CT-2003-505944); the Norwegian Foundation for Health and Rehabilitation; South-Eastern Norway Regional Health Authority and the Norwegian Diabetic Association. Grants were also obtained from the Freia Chocolade Fabriks Medical Foundation, Direkt{\o}r Johan Throne Holst Foundation for Nutrition Research, Norway. The authors thank the LIPGENE participants and the staff at all the clinical centers for their enthusiasm and support: Trinity College Dublin/University College Dublin, Ireland; University of Reading, UK; Oslo University Hospital Aker/University of Oslo, Norway; INSERM, Marseille, France; Maastricht University, The Netherlands; Hospital Universitario Reina Sof{\'i}a/University of C{\'o}rdoba, Spain; Jagiellonian Medical College, Krakow, Poland and Uppsala University, Sweden. Funding Information: The study has been supported by LIPGENE – an EU 6th Framework Program 阀ntegrated ?roject (FOOD-CT-2003-505944); the Norwegian Foundation for Health and Rehabilitation; South-Eastern Norway Regional Health Authority and the Norwegian Diabetic Association. Grants were also obtained from the Freia Chocolade Fabriks Medical Foundation, Direkt{\o}r Johan Throne Holst Foundation for Nutrition Research, Norway. Publisher Copyright: {\textcopyright} 2019 European Society of Endocrinology Printed in Great Britain.",
year = "2019",
month = may,
doi = "10.1530/EJE-19-0022",
language = "English",
volume = "180",
pages = "321--328",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "5",
}