Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs

J. Kalter; I. M. Verdonck-de Leeuw; M. G. Sweegers; N. K. Aaronson; P. B. Jacobsen; R. U. Newton; K. S. Courneya; J. F. Aitken; J. Armes; C. Arving; L. J. Boersma; A. M. J. Braamse; Y. Brandberg; S. K. Chambers; J. Dekker; K. Ell; R. J. Ferguson; M. F. M. Gielissen; B. Glimelius; M. M. Goedendorp; K. D. Graves; S. P. Heiney; R. Horne; M. S. Hunter; B. Johansson; M. L. Kimman; H. Knoop; K. Meneses; L. L. Northouse; H. S. Oldenburg; J. B. Prins; J. Savard; M. van Beurden; S. W. van den Berg; J. Brug; L. M. Buffart

doi:10.1002/pon.4648

Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs

J. Kalter, I. M. Verdonck-de Leeuw, M. G. Sweegers, N. K. Aaronson, P. B. Jacobsen, R. U. Newton, K. S. Courneya, J. F. Aitken, J. Armes, C. Arving, L. J. Boersma, A. M. J. Braamse, Y. Brandberg, S. K. Chambers, J. Dekker, K. Ell, R. J. Ferguson, M. F. M. Gielissen, B. Glimelius, M. M. GoedendorpK. D. Graves, S. P. Heiney, R. Horne, M. S. Hunter, B. Johansson, M. L. Kimman, H. Knoop, K. Meneses, L. L. Northouse, H. S. Oldenburg, J. B. Prins, J. Savard, M. van Beurden, S. W. van den Berg, J. Brug, L. M. Buffart^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

OBJECTIVE: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics.

METHODS: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.

RESULTS: PSI significantly improved QoL (β = 0.14,95%CI = 0.06;0.21), EF (β = 0.13,95%CI = 0.05;0.20), and SF (β = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types.

CONCLUSIONS: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.

Original language	English
Pages (from-to)	1150-1161
Number of pages	12
Journal	Psycho-Oncology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1002/pon.4648
Publication status	Published - 1 Apr 2018

Keywords

coping skills training
individual patient data meta-analysis
neoplasm
psychosocial care
psychotherapy
quality of life
RANDOMIZED CONTROLLED-TRIAL
THERAPY EFFECTIVENESS METAANALYSIS
COGNITIVE-BEHAVIOR THERAPY
BREAST-CANCER
PROSTATE-CANCER
PSYCHOLOGICAL ADJUSTMENT
MENOPAUSAL SYMPTOMS
FAMILY INTERVENTION
CLINICAL-TRIAL
BENEFITS

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Kalter, J., Verdonck-de Leeuw, I. M., Sweegers, M. G., Aaronson, N. K., Jacobsen, P. B., Newton, R. U., Courneya, K. S., Aitken, J. F., Armes, J., Arving, C., Boersma, L. J., Braamse, A. M. J., Brandberg, Y., Chambers, S. K., Dekker, J., Ell, K., Ferguson, R. J., Gielissen, M. F. M., Glimelius, B., ... Buffart, L. M. (2018). Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs. Psycho-Oncology, 27(4), 1150-1161. https://doi.org/10.1002/pon.4648

@article{792fc78166a0472292fcaab938ff23dd,

title = "Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs",

abstract = "OBJECTIVE: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics.METHODS: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.RESULTS: PSI significantly improved QoL (β = 0.14,95%CI = 0.06;0.21), EF (β = 0.13,95%CI = 0.05;0.20), and SF (β = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types.CONCLUSIONS: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.",

keywords = "coping skills training, individual patient data meta-analysis, neoplasm, psychosocial care, psychotherapy, quality of life, RANDOMIZED CONTROLLED-TRIAL, THERAPY EFFECTIVENESS METAANALYSIS, COGNITIVE-BEHAVIOR THERAPY, BREAST-CANCER, PROSTATE-CANCER, PSYCHOLOGICAL ADJUSTMENT, MENOPAUSAL SYMPTOMS, FAMILY INTERVENTION, CLINICAL-TRIAL, BENEFITS",

author = "J. Kalter and {Verdonck-de Leeuw}, {I. M.} and Sweegers, {M. G.} and Aaronson, {N. K.} and Jacobsen, {P. B.} and Newton, {R. U.} and Courneya, {K. S.} and Aitken, {J. F.} and J. Armes and C. Arving and Boersma, {L. J.} and Braamse, {A. M. J.} and Y. Brandberg and Chambers, {S. K.} and J. Dekker and K. Ell and Ferguson, {R. J.} and Gielissen, {M. F. M.} and B. Glimelius and Goedendorp, {M. M.} and Graves, {K. D.} and Heiney, {S. P.} and R. Horne and Hunter, {M. S.} and B. Johansson and Kimman, {M. L.} and H. Knoop and K. Meneses and Northouse, {L. L.} and Oldenburg, {H. S.} and Prins, {J. B.} and J. Savard and {van Beurden}, M. and {van den Berg}, {S. W.} and J. Brug and Buffart, {L. M.}",

year = "2018",

month = apr,

day = "1",

doi = "10.1002/pon.4648",

language = "English",

volume = "27",

pages = "1150--1161",

journal = "Psycho-Oncology",

issn = "1057-9249",

publisher = "Wiley",

number = "4",

}

Kalter, J, Verdonck-de Leeuw, IM, Sweegers, MG, Aaronson, NK, Jacobsen, PB, Newton, RU, Courneya, KS, Aitken, JF, Armes, J, Arving, C, Boersma, LJ, Braamse, AMJ, Brandberg, Y, Chambers, SK, Dekker, J, Ell, K, Ferguson, RJ, Gielissen, MFM, Glimelius, B, Goedendorp, MM, Graves, KD, Heiney, SP, Horne, R, Hunter, MS, Johansson, B, Kimman, ML, Knoop, H, Meneses, K, Northouse, LL, Oldenburg, HS, Prins, JB, Savard, J, van Beurden, M, van den Berg, SW, Brug, J & Buffart, LM 2018, 'Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs', Psycho-Oncology, vol. 27, no. 4, pp. 1150-1161. https://doi.org/10.1002/pon.4648

Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: An individual patient data meta-analysis of 22 RCTs. / Kalter, J.; Verdonck-de Leeuw, I. M.; Sweegers, M. G. et al.
In: Psycho-Oncology, Vol. 27, No. 4, 01.04.2018, p. 1150-1161.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer

T2 - An individual patient data meta-analysis of 22 RCTs

AU - Kalter, J.

AU - Verdonck-de Leeuw, I. M.

AU - Sweegers, M. G.

AU - Aaronson, N. K.

AU - Jacobsen, P. B.

AU - Newton, R. U.

AU - Courneya, K. S.

AU - Aitken, J. F.

AU - Armes, J.

AU - Arving, C.

AU - Boersma, L. J.

AU - Braamse, A. M. J.

AU - Brandberg, Y.

AU - Chambers, S. K.

AU - Dekker, J.

AU - Ell, K.

AU - Ferguson, R. J.

AU - Gielissen, M. F. M.

AU - Glimelius, B.

AU - Goedendorp, M. M.

AU - Graves, K. D.

AU - Heiney, S. P.

AU - Horne, R.

AU - Hunter, M. S.

AU - Johansson, B.

AU - Kimman, M. L.

AU - Knoop, H.

AU - Meneses, K.

AU - Northouse, L. L.

AU - Oldenburg, H. S.

AU - Prins, J. B.

AU - Savard, J.

AU - van Beurden, M.

AU - van den Berg, S. W.

AU - Brug, J.

AU - Buffart, L. M.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - OBJECTIVE: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics.METHODS: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.RESULTS: PSI significantly improved QoL (β = 0.14,95%CI = 0.06;0.21), EF (β = 0.13,95%CI = 0.05;0.20), and SF (β = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types.CONCLUSIONS: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.

AB - OBJECTIVE: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics.METHODS: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.RESULTS: PSI significantly improved QoL (β = 0.14,95%CI = 0.06;0.21), EF (β = 0.13,95%CI = 0.05;0.20), and SF (β = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types.CONCLUSIONS: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.

KW - coping skills training

KW - individual patient data meta-analysis

KW - neoplasm

KW - psychosocial care

KW - psychotherapy

KW - quality of life

KW - RANDOMIZED CONTROLLED-TRIAL

KW - THERAPY EFFECTIVENESS METAANALYSIS

KW - COGNITIVE-BEHAVIOR THERAPY

KW - BREAST-CANCER

KW - PROSTATE-CANCER

KW - PSYCHOLOGICAL ADJUSTMENT

KW - MENOPAUSAL SYMPTOMS

KW - FAMILY INTERVENTION

KW - CLINICAL-TRIAL

KW - BENEFITS

U2 - 10.1002/pon.4648

DO - 10.1002/pon.4648

M3 - (Systematic) Review article

SN - 1057-9249

VL - 27

SP - 1150

EP - 1161

JO - Psycho-Oncology

JF - Psycho-Oncology

IS - 4

ER -