Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery

S. Van Rijn; N. F. Rinsma; M. Y. A. van Herwaarden-Lindeboom; J. Ringers; H. G. Gooszen; P. J. J. van Rijn; R. A. Veenendaal; J. M. Conchillo; N. D. Bouvy; Adrian A. M. Masclee

doi:10.1038/ajg.2016.42

Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery

S. Van Rijn, N. F. Rinsma, M. Y. A. van Herwaarden-Lindeboom, J. Ringers, H. G. Gooszen, P. J. J. van Rijn, R. A. Veenendaal, J. M. Conchillo, N. D. Bouvy, Adrian A. M. Masclee^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Vagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS. METHODS: In the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)). RESULTS: Short-term follow-up: vagus nerve injury (PP peak

Original language	English
Pages (from-to)	508-515
Journal	American Journal of Gastroenterology
Volume	111
Issue number	4
DOIs	https://doi.org/10.1038/ajg.2016.42
Publication status	Published - Apr 2016

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Van Rijn, S., Rinsma, N. F., van Herwaarden-Lindeboom, M. Y. A., Ringers, J., Gooszen, H. G., van Rijn, P. J. J., Veenendaal, R. A., Conchillo, J. M., Bouvy, N. D., & Masclee, A. A. M. (2016). Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery. American Journal of Gastroenterology, 111(4), 508-515. https://doi.org/10.1038/ajg.2016.42

@article{a0aee7f880e042caa214ad030ec1500b,

title = "Effect of Vagus Nerve Integrity on Short and Long-Term Efficacy of Antireflux Surgery",

abstract = "OBJECTIVES: Vagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS. METHODS: In the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)). RESULTS: Short-term follow-up: vagus nerve injury (PP peak ",

author = "{Van Rijn}, S. and Rinsma, {N. F.} and {van Herwaarden-Lindeboom}, {M. Y. A.} and J. Ringers and Gooszen, {H. G.} and {van Rijn}, {P. J. J.} and Veenendaal, {R. A.} and Conchillo, {J. M.} and Bouvy, {N. D.} and Masclee, {Adrian A. M.}",

year = "2016",

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doi = "10.1038/ajg.2016.42",

language = "English",

volume = "111",

pages = "508--515",

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AU - Van Rijn, S.

AU - Rinsma, N. F.

AU - van Herwaarden-Lindeboom, M. Y. A.

AU - Ringers, J.

AU - Gooszen, H. G.

AU - van Rijn, P. J. J.

AU - Veenendaal, R. A.

AU - Conchillo, J. M.

AU - Bouvy, N. D.

AU - Masclee, Adrian A. M.

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N2 - OBJECTIVES: Vagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS. METHODS: In the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)). RESULTS: Short-term follow-up: vagus nerve injury (PP peak

AB - OBJECTIVES: Vagus nerve injury is a feared complication of antireflux surgery (ARS) that may negatively affect reflux control. The aim of the present prospective study was to evaluate short-term and long-term impact of vagus nerve injury, evaluated by pancreatic polypeptide response to insulin-induced hypoglycemia (PP-IH), on the outcome of ARS. METHODS: In the period from 1990 until 2000, 125 patients with gastroesophageal reflux disease (GERD) underwent ARS at a single center. Before and 6 months after surgery, vagus nerve integrity testing (PP-IH), 24-h pH-monitoring, gastric emptying, and reflux-associated symptoms were evaluated. In 2014, 14-25 years after surgery, 110 patients were contacted again for evaluation of long-term symptomatic outcome using two validated questionnaires (Gastrointestinal Symptom Rating Scale (GSRS) and GERD-Health Related Quality of Life (HRQL)). RESULTS: Short-term follow-up: vagus nerve injury (PP peak

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