@article{9d81e85eed0147c990e68ea8fca04e07,
title = "Effect of Interhospital Transfer on Endovascular Treatment for Acute Ischemic Stroke",
abstract = "Background and Purpose-To assess the effect of inter-hospital transfer on time to treatment and functional outcome after endovascular treatment (EVT) for acute ischemic stroke, we compared patients transferred from a primary stroke center to patients directly admitted to an intervention center in a large nationwide registry.Methods-MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Registry is an ongoing, prospective, observational study in all centers that perform EVT in the Netherlands. We included adult patients with an acute anterior circulation stroke who received EVT between March 2014 to June 2016. Primary outcome was time from arrival at the first hospital to arterial groin puncture. Secondary outcomes included the 90-day modified Rankin Scale score and functional independence (modified Rankin Scale score of 0-2).Results-In total 821/1526 patients, (54%) were transferred from a primary stroke center. Transferred patients less often had prestroke disability (227/800 [28%] versus 255/699 [36%]; P=0.02) and more often received intravenous thrombolytics (659/819 [81%] versus 511/704 [73%]; PConclusions-Interhospital transfer of patients with acute ischemic stroke is associated with delay of EVT and worse outcomes in routine clinical practice, even in a country where between-center distances are short. Direct transportation of patients potentially eligible for EVT to an intervention center may improve functional outcome.",
keywords = "patient transfer, registries, stroke, thrombectomy, time to treatment, LARGE-VESSEL OCCLUSION, INTRAVENOUS THROMBOLYSIS, THROMBECTOMY, OUTCOMES, TIME, RECANALIZATION, ASSOCIATION, REPERFUSION, PROTOCOL, VOLUME",
author = "Esmee Venema and Groot, {Adrien E.} and Lingsma, {Hester F.} and Wouter Hinsenveld and Treurniet, {Kilian M.} and Vicky Chalos and Zinkstok, {Sanne M.} and Mulder, {Maxim J. H. L.} and {de Ridder}, {Inger R.} and Marquering, {Henk A.} and Schonewille, {Wouter J.} and Wermer, {Marieke J. H.} and Majoie, {Charles B. L. M.} and Roos, {Yvo B. W. E. M.} and Dippel, {Diederik W. J.} and Coutinho, {Jonathan M.} and Bob Roozenbeek and {MR CLEAN Registry Investigators}",
note = "Funding Information: The Multicenter Randomized Clinical trial of EVT for AIS in the Netherlands (MR-CLEAN) Registry was partly funded by the Applied Scientific Institute for Neuromodulation (Toegepast Wetenschappelijk Instituut voor Neuromodulatie), the Erasmus University Medical Center, the Academic Medical Center Amsterdam, and the Maastricht University Medical Centre. Funding Information: The Multicenter Randomized Clinical trial of EVT for AIS in the Netherlands (MR–CLEAN) Registry was partly funded by the Applied Scientific Institute for Neuromodulation (Toegepast Wetenschappelijk Instituut voor Neuromodulatie), the Erasmus University Medical Center, the Academic Medical Center Amsterdam, and the Maastricht University Medical Centre. Funding Information: Academic Medical Center Amsterdam received funds from Stryker for consultations by C. Majoie and Y. Roos Erasmus University Medical Center received funds from Stryker and Bracco Imaging by D. Dippel. H. Marquering is co-founder and shareholder of Nico.lab. C. Majoie and Y. Roos own stock in Nico.lab. C. Majoie also reports research grants from the Applied Scientific Institute for Neuromodulation, the Dutch Heart Foundation, the European Commission and Stryker. D. Dippel received compensation for travel costs by Stryker and Medtronic. D. Dippel also reports research grants from Dutch Heart Foundation, Brain Foundation Netherlands, the Netherlands Organisation for Health Research and Development, and Health Holland Top Sector Life Sciences & Health, and unrestricted grants from AngioCare BV, Medtronic/Covidien/EV3, Medac Gmbh/Lamepro, Penumbra Inc, Stryker, Top Medical/Concentric, Thrombolytic Science LLC, and Stryker European Operations BV. Publisher Copyright: {\textcopyright} 2019 American Heart Association, Inc.",
year = "2019",
month = apr,
doi = "10.1161/STROKEAHA.118.024091",
language = "English",
volume = "50",
pages = "923--930",
journal = "Stroke",
issn = "0039-2499",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "4",
}